Publications by authors named "Bertrand Richert"
"Terra firma-forme dermatosis" on the proximal nail fold.
J Eur Acad Dermatol Venereol
November 2024
Article Synopsis
- Malignant tumors of the nail unit, like squamous cell carcinoma and basal cell carcinoma, can be hard to diagnose because they often look like benign issues, making early detection important.
- * This review examines various types of malignancies affecting the nail unit, discussing their clinical features, pathology, and surgical management challenges.
- * Proper evaluation and treatment strategies are critical for improving patient outcomes and preserving nail function during surgery.*
Current Knowledge on Nail Involvement in Autoimmune Bullous Disorders.
Skin Appendage Disord
October 2024
Article Synopsis
- Nail involvement in autoimmune bullous disorders presents diverse symptoms, often differing from skin manifestations, such as paronychia, onychomadesis, and onycholysis without blisters.
- Various autoimmune conditions like pemphigus vulgaris and bullous pemphigoid can cause nail changes, and the presence of Langerhans cells in the nails is noteworthy due to its unique immunological aspects.
- Diagnosing these nail issues typically requires histopathological and immunofluorescence tests, and researchers stress the need for more studies to improve treatment strategies for affected individuals.
Psoriasis, a chronic inflammatory skin disease, presents unique challenges when co-occurring with HIV. Tildrakizumab, an IL-23p19 inhibitor, has demonstrated efficacy in treating moderate-to-severe psoriasis. This retrospective case series reports three individuals living with HIV and psoriasis treated with tildrakizumab.
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- Malalignment of the great toenails is a frequently overlooked nail disorder that is not often recognized in general medical practice.
- The study reviewed 34 articles involving 117 patients, all exhibiting lateral deviation of the toenails along with yellow-brown discoloration and thickening.
- The findings highlight the need for increased awareness among healthcare providers to improve diagnosis and management of this underdiagnosed condition.
Article Synopsis
- The article discusses the need for a new classification system for retronychia, a condition affecting nails, using recent literature as a basis.* -
- It outlines various factors influencing retronychia, including the duration, severity, and types of nail displacement and alignment issues.* -
- The proposed classification system consists of three categories: Acute (A), Ongoing (O), and Chronic (C), aimed at improving diagnosis and understanding of the condition.*
Article Synopsis
- Onychoscopy is a non-invasive technique used to better diagnose nail disorders like nail psoriasis and lichen planus, providing detailed visual insights beyond a standard clinical examination.
- In nail psoriasis, key onychoscopic features include pitting, onycholysis with a red border, and specific patterns like salmon patches, while nail lichen planus shows signs like onychorrhexis and longitudinal melanonychia.
- There is limited literature on the use of onychoscopy for nail lichen striatus, and the features observed can vary between fingernails and toenails.
Article Synopsis
- The study investigates the expression of endothelial cell markers (SCF, VEGF, MAC) in skin affected by chronic spontaneous urticaria (CSU), using immunohistochemistry and serum analysis.
- Findings reveal that SCF is significantly more reactive in the lesional skin of CSU patients compared to healthy controls, especially in perivascular and epithelial cells.
- The research suggests that elevated levels of SCF in CSU skin indicate potential therapeutic avenues with anti-Kit antibodies for treatment.
Article Synopsis
- Onychomatricoma (OM) is a rare benign nail matrix tumor that requires surgical treatment, but there’s limited data on outcomes.
- A study reviewed 62 patients over 25 years, focusing on the relationship between the tumor's location, size, and postoperative results.
- The findings revealed that tangential excisions led to normal nail regrowth in 71% of cases, but tumors thicker than 3 mm or covering the entire nail plate had a higher risk of complications.
Article Synopsis
- "Green nails" or chloronychia is mainly caused by Pseudomonas bacteria, leading to a green discoloration of the nail along with other symptoms.
- The condition shows a typical triad of green nails, chronic paronychia (inflammation of the skin around the nail), and onycholysis (separation of the nail from its bed).
- Treatment involves removing the detached nail, applying a 2% sodium hypochlorite solution to the nail bed, and keeping the area dry by wearing latex gloves over cotton ones during daily tasks.
Nail cosmetics is enjoying growing success due to recent technological advances. Manicures can be responsible for mechanical, infectious or allergic adverse effects. Nail cosmetics (e.
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- Tumors in nails often act differently than those on the skin and have unique characteristics.
- Some tumors are specific to nails, while others prefer to grow around them.
- Treatment usually involves surgery, and doctors need to know the nail anatomy well to avoid problems later.
Chronic spontaneous urticaria: Evidence of systemic microcirculatory changes.
Clin Transl Allergy
January 2024
Background: Chronic spontaneous urticaria (CSU) is a chronic inflammatory skin disease where activation of endothelial cells (ECs) at sites of skin lesions leads to increased blood flow, leakage of fluid into the skin, cellular infiltration, and vascular remodeling. To understand the disease duration and the sometimes vague systemic symptoms accompanying flares, the objective of this study was to examine if CSU comes with systemic vascular changes at the microcirculatory level.
Methods: We investigated CSU patients (n = 49) and healthy controls (HCs, n = 44) for microcirculatory differences by nailfold videocapillaroscopy (NVC) and for blood levels of the soluble EC biomarkers serum vascular endothelial growth factor (VEGF), soluble E-selectin, and stem cell factor (SCF).
Onychomycosis is a fungal infection of the nail, and the most common nail infection worldwide, causing discoloration and thickening of the nail plate. It is predominantly caused by dermatophytes. Clinical presentation is polymorphous.
View Article and Find Full Text PDFUnderstanding the anatomy of the nail apparatus is a prerequisite for diagnosing and managing various nail disorders. The latter may be associated with systemic pathologies, or accompany infectious, inflammatory, tumoral, toxic or traumatic dermatoses. Before attempting to identify the cause, a rigorous clinical examination should be conducted to screen for elementary lesions that may affect general nail shape, nail surface, subungual attachments, periungual soft tissue or nail color.
View Article and Find Full Text PDFRecognizing and diagnosing the most common nail diseases is essential, to be able to guide patients and provide appropriate treatment. However, uncommon nail disorders should not be neglected, in order to avoid inadequate treatment and above all to ensure that no severe underlying disorder, with severe prognosis, is overlooked.
View Article and Find Full Text PDFFor decades, there has been debate about the cause of ingrown nail: is the nail plate or the periungual tissue at fault? There is no consensus and management relies on case-by-case analysis followed by tailored treatment. Conservative treatment should be attempted in children when the cause is transient (e.g.
View Article and Find Full Text PDFIntroduction: Kaposi sarcoma is an angioproliferative neoplasm. Its manifestations are well known but nail involvement seems extremely underreported.
Case Presentation: A 55-year-old man presented with a 6-month history of a growing subungual tumor affecting the third right toe.
Background: Onychopapilloma (OP) is a benign tumor of the nail. Haneke reported one case of malignant OP in 2021. No systematic immunohistochemistry study has been conducted on OP.
View Article and Find Full Text PDFBackground: Chronic urticaria (CSU) is a chronic inflammatory mast cell-driven disorder of which reliable clinical data in Belgium are lacking. This study focusses on clinical characteristics of CSU patients presenting at an urban Immunology-Allergology department.
Methods: Outpatients with CSU were included from 2018 to 2021.