[Regional management tool and analysis of hospital prescriptions delivered in community pharmacies: A different approach to support French health institutions].

Health economic regulation and relevance of care are key points for every industrialised country. To get a better medicalised control of expenditure developments, French hospitals contracts with regulation authorities (Agence Régionale de Santé) and healthcare insurance within a "contract for the improvement of the quality and efficiency of care" (CAQES). One of the monitored element is the expenses related to hospital initial prescriptions delivered in community pharmacies (PHEV).

[What academic training for pharmacy students for clinical pharmacy? Example of shared medication report].

Objectives: In 2018, the implementation of shared medication reports in pharmacy encourages pharmacists to cooperate with other healthcare professionals. This job allows a decrease of medication errors in elderly. This requires a reorganization of the training offered by universities (initial and continuing training).

[Interest of several pharmaceutical activities to secure the care pathway of elderly patients?].

Objectives: In order to prevent medication errors during patient's care pathway, all transition steps must be secured. The main objective of this study was to assess the interest of medication review at hospital discharge on the sustainability of therapeutic optimizations made during hospitalisation in a geriatric population.

Material And Methods: This was a three months prospective, single-centre study performed in an acute geriatric unit of a university hospital.

RECOTOX, a French initiative in ecotoxicology-toxicology to monitor, understand and mitigate the ecotoxicological impacts of pollutants in socioagroecosystems.

RECOTOX is a cross-cutting initiative promoting an integrated research to respond to the challenges of monitoring, understanding, and mitigating environmental and health impacts of pesticides in agroecosystems. The added value of RECOTOX is to develop a common culture around spatial ecotoxicology including the whole chain of pressure-exposure-impact, while strengthening an integrated network of in natura specifically equipped sites. In particular, it promotes transversal approaches at relevant socioecological system scales, to capitalize knowledge, expertise, and ongoing research in ecotoxicology and, to a lesser extent, environmental toxicology.

How can recovery be enhanced after single-stage laparoscopic management of CBD stones? Endoscopic treatment versus laparoscopic surgery.

Background: Single-stage management of CBD stones comprises simultaneous common bile duct (CBD) clearance and cholecystectomy. The CBD can be cleared by using endoscopic treatment (ET) or laparoscopic surgery (LS) alone.

Aims: To determine the most rapid recovery after the single-stage laparoscopic management of CBD stones.

Bevacizumab efficacy in metastatic colorectal cancer is dependent on primary tumor resection.

Purpose: Bevacizumab plus fluoropyrimidine-based chemotherapy is standard treatment for first-line and second-line metastatic colorectal cancer (mCRC). However, to date, there is no current biomarker predictive for the benefit of bevacizumab use for these patients. Preclinical data suggest that the presence of the primary tumor could be involved in less efficient antitumor activity of antiangiogenic agents, but no clinical data currently support this hypothesis.

Evaluation of laparoscopic treatment of common bile duct stones in a prospective series of 505 patients: indications and results.

Background: The aim of this prospective study was the evaluation of the laparoscopic treatment of common bile duct stones (CBDS) and its indications.

Methods: Five hundred five patients who underwent laparoscopic treatment of CBDS from October 1990 to September 2006 were included in the prospective study. The mean age of the patients was 63 years (range = 19-93).

Crystallographic investigation of the dried exudate of the major vestibular (Bartholin's) glands in women.

Objective: The aim of this study was to investigate the dried secretion of human major vestibular glands in order to establish its crystallographic pattern and to compare the data with those obtained for other human genital biopolymers.

Study Design: After air drying, samples were examined comparatively under transmitted and polarized light. At first sight, dehydrated vestibular fluid exhibits a fern-like crystallographic pattern very similar in appearance to those described in mid-cycle cervical mucus and bulbo-urethral fluid.

[Degradation of copper IUDs in utero. The process of metallic corrosion. A scanning electron microscope study].

Objective: The present investigation was carried out in order to study the process of metallic corrosion of copper IUD's in utero, to precise its dynamics and location along the IUD and to appraise the influence of eventual calcareous deposition.

Material And Methods: A total of 461 copper IUDs representing four standard models were screened by means of optical microscopy. Especially typical samples were studied at higher magnifications under the scanning electron microscope.

One hundred laparoscopic choledochotomies with primary closure of the common bile duct.

Background: Several technical approaches for laparoscopic CBD exploration (LCBDE) exist. Laparoscopic choledochotomy is required in some situations and whenever a transcystic approach fails. Biliary drainage after choledochotomy has a 5% morbidity rate and avoidance of biliary drains might therefore further improve the results of LCBDE.

Elective laparoscopic colonic resection for diverticular disease: results of a multicenter study in 179 patients.

Background: We undertook a retrospective multicenter study of elective laparoscopic sigmoidectomy for diverticulitis in order to assess the safety and the results of the procedure performed by a large number of surgeons.

Materials And Methods: Between January 1998 and April 1999, the French Society of Laparoscopic Surgery recruited retrospectively 179 patients from 10 surgical units, operated on for elective laparoscopic sigmoidectomy. There were 94 men and 85 women with a mean age of 58 years (range, 30-82).

[I.U.D. degradation in utero as a function of time: the phenomena of calcification. Radiocrystallographic and scanning electron microscopy study].

Objective: A study was undertaken in order to determine the frequency of the process of calcareous deposition, to clarify the nature of the deposits, their arrangement along the IUD and their possible influence on the appearance of metrorrhagias.

Material And Methods: A total of 408 coopper IUD's belonging to four standard models were observed by means of optical microscopy at low magnifications. The most typical samples were studied under the scanning electron microscope and deposits analyzed by crystallography.

[Treatment of common bile duct stones with laparoscopy. Retrospective multicenter study with 612 patients].

Objective: To analyse retrospectively the results of one-stage laparoscopic treatment for common bile duct stones in 19 surgical centers in France.

Patients: From January 1991 to July 1996, 612 patients with choledocholithiasis underwent laparoscopic treatment.

Results: Overall duct clearance was obtained in 489 of the 612 patients (80%): through the cystic duct in 222 of 380 patients (58.

Elective laparoscopic management of sigmoid diverticulitis. Results in a series of 110 patients.

Background: The aim of this study was to evaluate the results of elective laparoscopic treatment of sigmoid diverticulitis.

Methods: Between November 1991 and February 1998, 110 patients were treated by elective laparoscopic colectomy for sigmoid diverticulitis. The main data recorded were postoperation pain, return of bowel function, operation time, duration of hospital stay, and early and late complications.

[Atomic absorption spectrophotometry study of copper ion release by copper-bearing intrauterine devices].

Copper release from copper-bearing IUD's was studied in vitro and in vivo using atomic absorption spectrophotometry in deionized water, normal saline solution and normal ovulatory cervical mucus. In these media, copper release from a 375 mm2 DIU occurs without latency, showing comparable amounts for identical time intervals. Daily copper release was shown to be respectively 8 and 11 times higher in cervical mucus and normal saline solution than in deionized water.

Evaluation of laparoscopic management of common bile duct stones in 220 patients.

Background: The aim of this study was to evaluate the feasibility and results of laparoscopic management of common bile duct stones (CBDS).

Methods: From October 1990 to November 1996, 220 patients with CBDS have been managed laparoscopically. CBDS were suspected or diagnosed preoperatively in 130 patients (59.

Double sodium and potassium sulphates revealed by microprobe analysis in dried cervical mucus: a mid-cycle crystallographic index.

The use of physical techniques such as scanning electron microscopy and microprobe analysis permits the analysis of valuable details of the structure of dried samples of mid-cycle cervical mucus during the period of maximum ferning. From a crystallographic point of view, particular attention was paid to the location, morphology and chemical composition of anisotropic organic sulphate microstructures. As distinct from the isotropic sodium chloride pattern described by Papanicolaou, these appear in a narrow period of time corresponding to the middle of the period of maximum ferning.

[Results of laparoscopic treatment of diverticular sigmoiditis. Apropos of 85 cases].

The authors report their experience of laparoscopic management of sigmoid diverticulitis in 86 patients operated from november 1991 to december 1996. Out of them, 9 patients in whom sigmoiditis was revealed by an acute complication underwent an emergency procedure and 76 patients were operated electively. The mean hospital stay was 9.

Laparoscopic treatment of common bile duct stones.

Background/aims: Laparoscopic exploration of the common bile duct is technically possible. The aim of this prospective study was to evaluate the feasibility of the different techniques of laparoscopic treatment of common bile duct stones and their complications.

Materials And Methods: From October 1990 to December 1995, 161 patients, age from 18 to 92, underwent a laparoscopic treatment for choledocholithiasis.

Crystal content investigation in dried human bulbo-urethral gland (Cowper's) secretion.

The present study compiled the data furnished by 77 different specimens of human bulbo-urethral secretion obtained from 4 donors. It established that Cowper's fluid, allowed to dry at room temperature, gives rise to dendritic crystalline structures showing a remarkable pattern closely resembling fern leaves. In addition to the dendrites, which may develop in some other mucoid secretions and are known to be mainly composed of NaCl crystals, numberless tiny spherulites are also observed within interdendritic intervals, in the central part of the preparations.

[Laparoscopic treatment of common bile duct calculi].

Laparoscopic exploration of the common bile duct is now technically possible. This prospective study evaluates the feasibility of the different techniques and their complications. From January 1990 to March 1995, 140 patients, aged from 22 to 92, underwent laparoscopic treatment for choledocholithiasis.

[The major Bartholin vestibular glands and their secretion: anatomy, physical properties, and physiological roles].

The present article summarizes observations and experimental data obtained from the major vestibular Bartholin's glands in both human and animals with special reference to glandular anatomy as wells as chemical composition, physical properties and physiological roles of the vestibular secretion.