Synergistic relaxing effect of the paracetamol and pyrilamine combination in isolated human myometrium.

Objective: To evaluate the interaction type of the human uterine relaxant effect of the paracetamol-pyrilamine combination (PPC) in vitro.

Study Design: Uterine strips were contracted with KCl (60 mM) and treated with vehicle or increasing concentrations of paracetamol (100-3200 μM), pyrilamine (3.2-100 μM) or the PPC.