Abnormal E-cadherin expression and prostate cell blood dissemination as markers of biological recurrence in cancer.

Until now, no molecular parameter has been available for predicting the metastatic potential of prostate tumours, which leaves their outcome uncertain despite an apparent benign histology or early stage. Abnormal expression of adhesion molecules, such as E-cadherin, can be contributing factors for increased invasiveness and metastatic potential. Histological analysis for E-cadherin expression was carried out on paraffin-embedded tumour tissues.

Blood-borne RT-PCR assay for prostasin- specific transcripts to identify circulating prostate cells in cancer patients.

Objective: The aim of this study was to establish the specific detection of prostasin-expressing prostate cells in the blood of patients with prostate cancer.

Patients And Methods: A prostasin-specific RT-PCR assay was developed and optimized using limiting dilutions of cell line LNCaP mixed with normal blood specimens. Then, it was used to examine peripheral blood samples from 96 patients with prostate cancer (localized carcinoma, n = 69, metastatic, n = 27).

Molecular expression of PSMA mRNA and protein in primary renal tumors.

Human prostate-specific membrane antigen (PSMA), a 100-kDa integral transmembrane glycoprotein, is considered to be a highly specific marker of the prostate gland, and has successfully been used as a marker of circulating prostatic epithelial cells. Extended PSMA homology has been demonstrated with a cDNA found in rat cerebral and renal tissues. In this study, we aimed to evaluate the expression of PSMA mRNA in a variety of human renal cancer tissues (n = 20) and cell lines (n = 12).

[Vertical transmission of the human T-cell leukemia virus in an endemic area. An epidemiological study in children from 0 to 5 years in Gabon].

A seroepidemiological survey was conducted in a representative population of children aged 0-5 in Gabon. Breast-feeding appears to an important mode of HTLV vertical transmission. Owing to other epidemiological data in population of gabonese adults allow us to think that breast-feeding related transmission and sexual transmission seem to occur in equal proportion in the global HTLV transmission in that area of endemicity.

[The association of acute polyradiculoneuritis, transitory diabetes insipidus and pregnancy. Apropos of a case and review of the literature].

This is the first report of the association of transitory diabetes insipidus with acute infective polyneuritis (landry Guillain-Barre Syndrome) occurring in pregnancy. The authors try to establish the inter-relationship between each pathological condition and pregnancy. Polyneuritis in its severe form does not seem to increase the risk of prematurity significantly.

Evaluation of the teratogenic potential of three aliphatic nitriles in the rat.

Acetonitrile (ACN), adiponitrile (ADN), and propionitrile (PN), were evaluated for embryotoxic and teratogenic potential in rats. Mated Sprague-Dawley rats were administered one of the three nitriles by gavage on gestation Days 6-19, inclusive. Daily dosage levels (mg/kg body wt) were: ACN at 0, 125, 190, and 275; ADN at 0, 20, 40, and 80; PN at 0, 20, 40, and 80.

[Idiopathic aneurysm of the left ventricle. Apropos of 4 cases operated on with success].

Over a period of 3 years, 4 cases of idiopathic left ventricular aneurysm, 3 white females and one coloured male aged 34, 53, 29 and 47 years respectively, were observed. All presented with paroxysmal ventricular or supraventricular tachycardia, which, in one case, was severe enough in itself to justify surgery. On angiography, large left ventricular aneurysms bordering the mitral annulus and responsible for moderate mitral regurgitation in two patients were demonstrated.

Pyrethroid-like biological activity of compounds lacking cyclopropane and ester groupings.

The following new insecticidal compounds respond to synergism by piperonyl butoxide and block nerve excitability in the same manner as the insecticide allethrin: 1-(4-allethronyl)-acetyl-2,2-dimethyl-3-isobutenylcyclopropane (the ketone analog of allethrin) and the esters of 5-benzyl-3 furylmethanol with 2,2,3,3-tetramethylcyclopropanecarboxylic acid, 2,2,3,3-tetramethylaziridinecarboxylic acid, and N, N-diisopropylcarbamic acid. Therefore pyrethroid-like activity is not restricted to esters of cyclopropanecarboxylic acids.