Publications by authors named "Bert Groen"

Article Synopsis
  • Amino acids, especially histidine, can influence metabolism and glycemic control, primarily investigated through a clinical study involving participants with type 2 diabetes and healthy controls.
  • After two weeks of oral histidine supplementation, researchers saw improved glycemic markers and an increase in MAIT cells, suggesting a link between histidine metabolism, gut bacteria, and immune response.
  • The study proposes that dietary histidine may affect MAIT cells through changes in gut microbiota and specific gene expression, highlighting potential pathways for future research in managing glycemic control.
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Fatty-acid metabolism plays a key role in acquired and inborn metabolic diseases. To obtain insight into the network dynamics of fatty-acid β-oxidation, we constructed a detailed computational model of the pathway and subjected it to a fat overload condition. The model contains reversible and saturable enzyme-kinetic equations and experimentally determined parameters for rat-liver enzymes.

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