Risk factors for cardiogenic shock in thyroid storm: a retrospective and case-series study.

Thyroid storm (TS) occurs in 10% of thyrotoxicosis patients and 1% of TS patients experience cardiogenic shock (CS), which is associated with poor prognosis. This is a single institution, retrospective study in which 56 patients with TS were evaluated. BMI (p = 0.

Mixed Warm and Cold Autoimmune Hemolytic Anemia With Concomitant Immune Thrombocytopenia Following Recent SARS-CoV-2 Infection and Ongoing Rhinovirus Infection.

Mixed-type autoimmune hemolytic anemia (AIHA) is a term used to describe hemolysis occurring in the context of both warm and cold reactive autoantibodies to red blood cells. Immune thrombocytopenia (ITP) is an acquired form of thrombocytopenia potentially complicated by hemorrhage due to autoantibodies reactive with platelets and megakaryocytes. Diagnosis of ITP requires exclusion of other known causes of thrombocytopenia.

Blending technology and teamwork for successful management of product recalls.

Patient safety programs have been developed in many hospitals to reduce the risk of harm to patients. Proactive, real-time, and retrospective risk-reduction strategies should be implemented in hospitals, but patient safety leaders should also be cognizant of the risks associated with thousands of products that enter the hospital through the supply chain. A growing number of recalls and alerts related to these products are received by health care facilities each year, through a recall process that is fraught with challenges.

Screening protocol for MR imaging of the internal auditory canal.

We have previously shown that 5 mm axial T1-weighted images following Gd-diethylenetriamine pentaacetic acid (DTPA) administration were sufficient as a screening examination of the internal auditory canal (IAC) and cerebellopontine angle cistern in 80% of cases with sensorineural hearing loss. In the remaining 20% of cases 3 mm slices were necessary for confirmation of the diagnosis. To reduce the number of cases requiring the additional examination, we have modified our protocol to include a coronal "scout" T1-weighted sequence followed by 5 mm axial sections angled through the IACs.

Imaging of degenerative brain disorders.

Recent advances have been made in defining the imaging findings associated with degenerative brain disorders, especially Alzheimer's disease, multi-infarct dementia, and multiple sclerosis. CT and MR imaging are capable of evaluating structural changes seen in these abnormalities. Positron emission tomography and single-photon emission CT studies, by evaluating metabolic changes, may demonstrate abnormalities before those seen on CT or MR imaging.

An automated instrument for the performance of enzymatic DNA sequencing reactions.

An instrument has been developed for the automation of enzymatic DNA sequencing reactions. Up to 96 DNA templates contained in a microtiter plate can be processed for either radioactive or fluorescence-based sequence analysis in a three-hour period. The quality of the resultant data is comparable to that obtained manually.

Case report 621. Multiple myeloma (IgD) in a 28-year-old woman.

A 28-year-old woman with IgD myeloma was described. The patient presented with pain in the anterior wall of the chest, and tenderness over the ribs, thoracic spine, and right shoulder. A radionuclide bone scan showed increased uptake along the costochondral junctions, ribs, and shoulders, with the diffuse uptake in the costochondral junction being typical for costochondritis.

Case report 603. Giant cell reparative granuloma of the distal end of right femur.

A GCRG of the femur in a 57-year-old man was described. He had undergone local radiotherapy and systemic chemotherapy for T-cell lymphoma of the jaw and scalp diagnosed 4 weeks previously. Since radiologically the lesion suggested an aggressive process, malignant lymphoma was the most probable preoperative diagnosis.

Tuberculous abscess of the pancreas in AIDS: CT findings.

Tuberculous abscess of the pancreas is a rare complication of disseminated tuberculosis. The computed tomographic appearance of a tuberculous pancreatic abscess in a patient with acquired immune deficiency syndrome (AIDS) is described. One should consider this diagnosis whenever a patient with AIDS has diffuse abdominal lymphadenopathy.

Computed tomography of mediastinal collaterals in SVC syndrome.

A patient undergoing treatment for abdominal lymphoma presented with a superior vena cava (SVC) syndrome. The presence of a wide mediastinum and "nodular" mediastinal densities on CT presented a diagnostic problem, necessitating thoracotomy. The thoracotomy was negative for tumor or infection.

Mechanism of interaction between endogenous ecotropic murine leukemia viruses in (BALB/c X C57BL/6) hybrid cells.

The germline ecotropic murine leukemia (MuLV) proviruses of BALB/c and C57BL/6 (B6) mice were analyzed to determine the molecular basis of low virus expression in these mouse strains and to determine the mechanism of interaction of these two proviruses. Previous work had demonstrated that the BALB/c endogenous ecotropic provirus was infectious but unable to induce XC cell syncytia formation, and that induced (BALB/c X B6) hybrid cells expressed 10- to 50-fold more XC syncytia than induced parental cells. Two independently isolated DNA clones of the B6 endogenous ecotropic provirus were noninfectious following transfection into cells, and cell lines that expressed this viral genome produced noninfectious MuLV.

Injuries to runners: a study of entrants to a 10,000 meter race.

As the number of runners has increased dramatically, so has the incidence of running-related injuries. In order to determine what training factors are associated with running-related injuries, as well as what percentage of injured runners seeks professional medical attention, a random sample of entrants to a 10 kilometer race was asked to complete a questionnaire. There were 451 respondents, 355 men and 96 women, with a nonresponse rate of 12.

Diversity in the germline antibody repertoire. Molecular evolution of the T15 VN gene family.

The T15 heavy chain variable region (VH) gene family in BALB/c mice includes four elements each greater than 88% homologous with the other. One of these elements, V1, encodes virtually all of the VH regions in BALB/c antiphosphorylcholine antibodies, while another element, V3, is a pseudogene and cannot be transcribed or translated. We have examined the structural features of this VH gene family in other mouse strains and, in particular, have cloned and sequenced the alleles of these gene segments present in B10.

Phosphate-binding specificities of monoclonal antibodies against phosphoinositides in liposomes.

Monoclonal antibodies against phosphatidylinositol phosphate were produced after injecting a mouse with liposomes containing dimyristoylphosphatidylcholine, cholesterol, phosphatidylinositol phosphate and lipid A. The antibodies raised were IgM (kappa) and their activities were assayed by complement-dependent damage to liposomes lacking lipid A but containing the rest of original immunizing mixture of lipids. Three of the four antibodies selected cross-reacted with liposomes containing phosphatidylinositol instead of phosphatidylinositol phosphate; and two of the antibodies cross-reacted with liposomes containing phosphatidylinositol diphosphate.

Discoid medial meniscus: two cases of tears presenting as locked knee due to athletic trauma.

Two patients with a rare, massive type of discoid medial meniscus have been described. Both presented with a locked knee due to athletic trauma in the third and fifth decade of life, respectively. Clinically, discoid meniscus has only nonspecific signs.

Human fibroblast interferon in treatment of viral diseases of the skin and mucous membranes.

The therapeutic effect of human fibroblast interferon (HFIF) was studied in 33 patients. Seven had ophthalmic lesions (three due to adenovirus Type 8, four to herpes simplex virus, and one to herpes zoster) and were treated with HFIF. In the four patients with herpes simplex keratitis, HFIF was given in addition to standard therapy or together with other antiviral agents.

Vasopressin-induced antinociception: an investigation into its physiological and hormonal basis.

Systemically administered lysine-8-vasopressin (LVP; 16-128 micrograms/kg) was found to induce a potent and dose-dependent antinociceptive effect, as measured by the tail-flick test in the rat. This effect could be seen in the absence of any significant change in general activity, indicating that it was not due to sedation or general motor debilitation. The antinociceptive effect of LVP does not appear to be mediated by endogenous opiates or other pituitary hormones, as evidenced by: 1) the lack of antagonism by the opiate receptor blocker naloxone, 2) the lack of cross-tolerance with morphine, and 3) its persistence after hypophysectomy.

The nucleotide sequence of a human immunoglobulin C gamma1 gene.

We report the nucleotide sequence of a gene encoding the constant region of a human immunoglobulin gamma 1 heavy chain (C gamma 1). A comparison of this sequence with those of the C gamma 2 and C gamma 4 genes reveals that these three human C gamma genes share considerable homology in both coding and noncoding regions. The nucleotide sequence differences indicate that these genes diverged from one another approximately 608 million years ago.

Diagnosis of popliteal cyst: double-contrast arthrography and sonography.

One hundred consecutive patients who had trauma to the knee were examined by sonography and double-contrast arthrography to evaluate the presence or absence of popliteal cyst. In 58 cases both tests were negative, while in 15 both were positive. Each of those 15 patients had pain and/or a palpable mass behind the knee.

An epidemiologic study of squash injuries.

A retrospective investigation of squash-related injuries incurred at a private and a public club in New York was undertaken to gain insight into the incidence and nature of such injuries. Telephone interviews were conducted with 200 randomly selected individuals to obtain their entire injury history. Sixty-nine of the 155 squash players contacted sustained injuries during their participation.