Gadolinium-DTPA in the magnetic resonance evaluation of the postoperative patient. Work in progress.

The application of gadolinium-DTPA to magnetic resonance scanning has been demonstrated to have considerable potential. Because the evaluation of the post-operative patient is particularly difficult for magnetic resonance due to the non-specific appearance of surgical trauma and edema, we attempted to formulate some preliminary impressions regarding the use of gadolinium-DTPA in this setting based on our experience with 15 patients studied at varying intervals following surgery, from 2 days to 8 years. Specifically, the time course and appearance of normal post-surgical enhancement was found to exhibit certain patterns.

Combined magnetic resonance imaging and bihemispheric magnetic resonance spectroscopy in acute experimental focal cerebral ischemia.

Combined magnetic resonance imaging (MRI) and 31P-magnetic resonance spectroscopy (MRS) were employed to evaluate acute regional cerebral ischemia in cats following middle cerebral artery occlusion (MCAO). MRI changes were first reliable 3 hours after MCAO; progressive increases in T1 and T2 relaxation times were noted for 12 hours after MCAO. Immediately after MCAO, 31P-MRS revealed decreased phosphocreatine (PCr) and increased inorganic phosphate (Pi); the PCr/Pi ratio fell from 2.

Magnetic resonance imaging in the evaluation of nimodipine-treated acute experimental focal cerebral ischemia.

We evaluated the sensitivity of magnetic resonance (MR) imaging in documenting effects of nimodipine in experimental focal cerebral ischemia. Twenty-five Sprague Dawley rats underwent unilateral occlusion of the middle cerebral artery and were imaged at different intervals thereafter. Neuropathologic and neurologic data were correlated with MR imaging results.

Combined magnetic resonance imaging and spectroscopy in experimental regional injury of the brain. Ischemia and impact trauma.

Combined magnetic resonance imaging (MRI) and spectroscopy (MRS) allows unique experimental insights into the central nervous system (CNS) disorders. Clinical applications are forthcoming. In order to address the potential clinical uses of MRI/MRS, experimentally induced focal brain lesions were evaluated with this modality.

Aversion substance(s) of the rat coagulating glands.

The aversive substance(s) present in adult male urine were not found in castrate rat urine. Removal of the coagulating glands also resulted in a loss of the aversion compounds. The aversion substances were restored to the urine after androgen treatment of the castrate rats.