Publications by authors named "Berrin Zık"
The aim of the present study is to investigate the proliferative or apoptotic effects of different doses and durations of Royal jelly (RJ) on serous type epithelial ovarian cancer, which is the most common epithelial ovarian cancer. For this purpose, cells of the Skov-3 human ovarian adenocarcinoma cell line were grown in McCoy medium and seeded in 6-well plates. RJ was prepared as a stock solution (1000 mg RJ/10 ml dHO) and 1, 5, 10, 20, and 50 mg/ml RJ doses from the prepared stock solution were added to the medium for 24, 48, and 72 h incubated.
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- The study investigates how bisphenol A (BPA), a common plastic chemical, impacts the formation and health of primordial follicles in the ovary, which are key for female reproduction.
- It highlights the crucial role of the Notch signaling pathway in the communication between oocytes and pregranulosa cells for Folliculogenesis, which BPA might disrupt.
- The research findings reveal that BPA exposure affects the number of ovarian follicles, levels of cell death (apoptosis), and the expression of Notch2 and Jagged2 proteins, with effects varying based on the dosage and timing of exposure.
Article Synopsis
- TGFβ proteins induce the epithelial-mesenchymal transition (EMT) in tumor cells, with Dual Specificity Phosphatases (DUSPs) playing a potential but unclear role in this process.
- Research on A549 lung cancer and PANC1 pancreatic cancer cells revealed that TGFβ1 increased expressions of certain DUSP genes and resulted in changes in EMT-related proteins through MAPK pathway activation.
- Specifically, silencing DUSP26 was found to significantly reduce TGFβ1's effects on E-cadherin and mesenchymal gene expressions, indicating that DUSP26 may be necessary for TGFβ1-induced EMT in these cancer models.
Article Synopsis
- - TGFβ proteins trigger an epithelial-mesenchymal transition (EMT) in carcinoma cells, making them more invasive and resistant to drugs, through pathways involving both SMAD and MAPK proteins.
- - The study focuses on dual-specificity phosphatases (DUSPs) that regulate the activity of ERK1/2, and found that TGFβ1 stimulation decreases the expression of DUSP4 and DUSP13.
- - Co-expressing DUSP4 and DUSP13 in A549 cells dampens TGFβ1-induced ERK1/2 activation and reduces migration, invasion, and drug resistance, highlighting their potential role in combating TGFβ1-driven malignancy.
Effects of capsaicin on ovarian granulosa cell proliferation and apoptosis.
Cell Tissue Res
June 2018
Article Synopsis
- Capsaicin, the active component in red peppers, is known for treating pain and inflammation but has limited research on its effects specifically on ovarian granulosa cells.
- This study aimed to investigate how different doses of capsaicin influence cell growth (proliferation) and cell death (apoptosis) in these ovarian cells over 24 and 48 hours.
- The findings indicate that low doses of capsaicin administered for a short period can enhance the proliferation of granulosa cells, suggesting a potential positive effect on the development of ovarian follicles.
Effect of tamoxifen on ovarian reserve: A randomized controlled assessor-blind trial in a mouse model.
J Turk Ger Gynecol Assoc
January 2015
Article Synopsis
- The study aimed to investigate whether tamoxifen (TMX) exposure causes a lasting reduction in ovarian reserve in female mice.
- Results showed that mice treated with TMX had lower serum anti-Müllerian hormone (AMH) levels and smaller ovaries compared to the control group, indicating impaired ovarian function.
- However, while TMX affected the growth of certain follicle types, it did not reduce the number of primordial follicles, suggesting TMX primarily disrupts hormone-sensitive follicles rather than the overall follicle pool.
The Fas/Fas Ligand (FasL) system and survivin have counteracting roles in cell survival. Therefore, we explored the role of circulating soluble Fas (sFas) and the tissue levels of Fas and survivin with regard to response to chemotherapy in lung cancer patients. Serum samples from 52 lung cancer patients and 54 control subjects (19 benign lung disease and 35 healthy control subjects) were collected prior to and 24 and 48 h after chemotherapy.
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- Capsaicin, found in red pepper, impacts sensory neurons and is consumed by various ethnic groups, with both high and chronic low doses affecting the body differently.
- A study on Sprague-Dawley rats examined the effects of low-dose capsaicin injections over 6 and 19 days, finding that short-term exposure reduced Substance P (SP) levels in lung and skin, while long-term exposure allowed SP levels to return to normal due to increased synthesis.
- The results suggest that long-term, low-dose capsaicin may enhance sensory nerve function and affect SP levels in non-neuronal tissues, with younger rats displaying significantly decreased SP levels compared to older rats.
Article Synopsis
- * Chickens on the pepper diet showed quicker reproductive organ development and began laying eggs 11 days earlier than those on a standard diet.
- * Results suggested that while weight gain initially favored the pepper group, it reversed by month five, and further research is needed on abdominal fat reduction and lipid metabolism effects.