Publications by authors named "Berre Van Moer"
Article Synopsis
- Komagataella phaffii, formerly known as Pichia pastoris, is widely used for producing recombinant proteins for therapeutics and food, but the original strain NRRL Y-11430 is restricted.
- Researchers identified the NCYC 2543 strain from 1954 as a foundation for developing an open-access strain called OPENPichia, designed to enable widespread use without restrictions.
- By modifying the HOC1 gene in NCYC 2543, the team enhanced its ability to take up DNA and improve protein secretion, providing a genome-sequenced strain and a versatile expression vector toolkit for the biotech community.
Article Synopsis
- Antibody-based drugs, especially IgG monoclonal antibodies, are widely used to treat various diseases such as cancer and autoimmune disorders, owing to their specialized therapeutic properties.
- The efficacy and functionality of IgG antibodies are influenced by specific modifications in their sugar structures (glycoforms), which affect how they interact with other cells and proteins in the body.
- To improve the effectiveness of these antibodies, researchers are exploring advanced engineering methods to create antibodies with customized glycoforms through techniques like using engineered cell lines and glycoengineering approaches.
While transcriptome- and proteome-wide technologies to assess processes in protein biogenesis are now widely available, we still lack global approaches to assay post-ribosomal biogenesis events, in particular those occurring in the eukaryotic secretory system. We here develop a method, SECRiFY, to simultaneously assess the secretability of >10 protein fragments by two yeast species, S. cerevisiae and P.
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