Publications by authors named "Bernie Byunghoon Park"
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Thymic stromal lymphopoietin (TSLP) plays an important role in the differentiation and proliferation of Th2 cells, resulting in eosinophilic inflammation and numerous allergic diseases. Baicalein (1), a major component of Scutellaria baicalensis, was found to be the first small molecule to block TSLP signaling pathways. It inhibited effectively eosinophil infiltration in house dust mite-induced and ovalbumin-challenged mouse models.
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- The study developed a new method called cassette PAMPA to test the intestinal permeability of lipophilic compounds in drug discovery.
- This method utilized a double-sink setup with a pH gradient and a surfactant to improve the accuracy of permeability screening, especially for certain compounds.
- Results showed that initial tests had two false negatives, but adding polysorbate 80 improved recovery and permeability, allowing clear differentiation of compound classes and a strong correlation with existing permeability data.
Identification of potent agonists of odorant receptors (ORs), a major class of G protein-coupled receptors, remains challenging due to complex receptor-ligand interactions. ORs are present in both olfactory and non-chemosensory tissues, indicating roles beyond odor detection that may include modulating physiological functions in non-olfactory tissues. Selective and potent agonists specific for particular ORs can be used to investigate physiological functions of ORs in non-chemosensory tissues.
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