Regulation of centrosome movements by numb and the collapsin response mediator protein during Drosophila sensory progenitor asymmetric division.

Asymmetric cell division generates cell fate diversity during development and adult life. Recent findings have demonstrated that during stem cell divisions, the movement of centrosomes is asymmetric in prophase and that such asymmetry participates in mitotic spindle orientation and cell polarization. Here, we have investigated the dynamics of centrosomes during Drosophila sensory organ precursor asymmetric divisions and find that centrosome movements are asymmetric during cytokinesis.

High-resolution multislice computerized tomography with multiplanar and 3-dimensional reformation imaging in rapid palatal expansion.

Introduction: The purpose of this study was to evaluate whether high-resolution multislice computerized tomography (CT) with multiplanar reformation and 3-dimensional (3D) imaging is helpful in demonstrating the effects on midfacial sutures induced by rapid palatal expansion (RPE), thereby appraising and corroborating the current state of the art or possibly adding new findings.

Methods: Two patients in different stages of skeletal maturity (aged 10 and 16 years) underwent CT examinations immediately after active opening with the RPE appliance.

Results: The 3D CT imaging method proved to be valuable in visualizing skeletal effects on not only the midpalatal suture, but also adjacent sutures.

Per-sextant localization and staging of prostate cancer: correlation of imaging findings with whole-mount step section histopathology.

Objective: The objective of our study was to determine the diagnostic accuracy and interobserver agreement of 1.5-T prostatic MRI for per-sextant tumor localization and staging of prostate cancer as compared with whole-mount step section histopathology.

Materials And Methods: Combined endorectal-pelvic phased-array prostatic MRI scans obtained at 1.

MRI-based PSA density and PSA density of the transitional zone compared with PSA alone: correlation with prostate cancer Gleason score.

Objectives: The tumor Gleason score is an important prognostic factor in prostate cancer (PCA). This retrospective study analyzes whether serum prostate-specific antigen (PSA), or magnetic resonance imaging (MRI)-based PSA density of the entire prostate (PSAD) or the prostatic transitional zone (PSAT) distinguishes between PCA of Gleason scores 6 or lower (G6-) and 7 or higher (G7+).

Materials And Methods: Total prostate and transitional zone volumes were planimetrically determined in axial, T2-weighted fast spin echo (FSE) MRI images of the prostate in 61 patients with previously untreated PCA.

The exocyst component Sec5 is present on endocytic vesicles in the oocyte of Drosophila melanogaster.

The exocyst is an octameric complex required for polarized secretion. Some components of the exocyst are found on the plasma membrane, whereas others are recruited to Golgi membranes, suggesting that exocyst assembly tethers vesicles to their site of fusion. We have found that in Drosophila melanogaster oocytes the majority of the exocyst component Sec5 is unexpectedly present in clathrin-coated pits and vesicles at the plasma membrane.