Retinitis pigmentosa: rapid neurodegeneration is governed by slow cell death mechanisms.

For most neurodegenerative diseases the precise duration of an individual cell's death is unknown, which is an obstacle when counteractive measures are being considered. To address this, we used the rd1 mouse model for retinal neurodegeneration, characterized by phosphodiesterase-6 (PDE6) dysfunction and photoreceptor death triggered by high cyclic guanosine-mono-phosphate (cGMP) levels. Using cellular data on cGMP accumulation, cell death, and survival, we created mathematical models to simulate the temporal development of the degeneration.

Thermal comfort range of a military cold protection glove: database by thermophysiological simulation.

The thermal insulation properties of a military wet/cold protection glove of the German Bundeswehr were investigated using the thermophysiological simulation device CYBOR with a heated full-scale hand model. The aim of this study was the physiology related and more reliable estimation of a database for the thermal comfort range of the glove in terms of environmental limit temperatures and maximum safe wearing times (limit times). For that purpose the simulation device CYBOR is equipped with a control feature allowing the simulation of the physiological effect that the blood flow into the hands as the dominant heat source is reduced with decreasing skin temperature (vasoconstriction effect).