Frequency-dependent selection of alternative spinal pathways with common periodic sensory input.

Electrical stimulation of the lumbar cord at distinct frequency ranges has been shown to evoke either rhythmical, step-like movements (25-50 Hz) or a sustained extension (5-15 Hz) of the paralysed lower limbs in complete spinal cord injured subjects. Frequency-dependent activation of previously "silent" spinal pathways was suggested to contribute to the differential responsiveness to distinct neuronal "codes" and the modifications in the electromyographic recordings during the actual implementation of the evoked motor tasks. In the present study we examine this suggestion by means of a simplified biology-based neuronal network.