Publications by authors named "Bernhard Florian Roeck"
Article Synopsis
- The cytokine TNF can lead to a type of cell death influenced by RIPK1, but this can be suppressed by two proteins, TANK and AZI2, which help regulate TBK1 kinase activation.
- Mice lacking both TANK and AZI2 experience severe health issues like multi-organ inflammation and early death, which can be mitigated by disabling TNFR1 or using a modified RIPK1.
- TANK and AZI2 work together in the TNF receptor signaling process, binding to different components at distinct times to maintain TBK1 activity and protect against excessive inflammation.
