A novel approach to decannulation of a tracheostomy tube using a 1-way speaking valve after upper airway trauma in 2 dogs.

Objective: To describe a novel approach to tracheostomy management in dogs with upper airway trauma.

Case Series Summary: Two dogs with upper airway trauma presented to an emergency department and required immediate intubation. To minimize sedation time, tracheostomy tubes were placed in both dogs.

Targeted radionuclide therapy against GARP expressing T regulatory cells after tumour priming with external beam radiotherapy in a murine syngeneic model.

Purpose: Radiation therapy (RT) exerts its anti-tumour efficacy by inducing direct damage to cancer cells but also through modification of the tumour microenvironment (TME) by inducing immunogenic antitumor response. Conversely, RT also promotes an immunosuppressive TME notably through the recruitment of regulatory T cells (Tregs). Glycoprotein A repetitions predominant (GARP), a transmembrane protein highly expressed by activated Tregs, plays a key role in the activation of TGF-β and thus promotes the immunosuppressive action of Tregs.

Preoperative PET imaging and fluorescence-guided surgery of human glioblastoma using dual-labeled antibody targeting ET receptors in a preclinical mouse model: A theranostic approach.

Glioblastoma (GBM) poses significant challenges regarding complete tumor removal due to its heterogeneity and invasiveness, emphasizing the need for effective therapeutic options. In the last two decades, fluorescence-guided surgery (FGS), employing fluorophores such as 5-aminolevulinic acid (5-ALA) to enhance tumor delineation, has gained attraction among neurosurgeons. However, some low-grade tumors do not show any accumulation of the tracers, and the lack of patient stratification represents an important limitation.

Unraveling the origin of Kondo-like behavior in the 3-electron heavy-fermion compound YFeGe.

The heavy fermion (HF) state of [Formula: see text]-electron systems is of great current interest since it exhibits various exotic phases and phenomena that are reminiscent of the Kondo effect in [Formula: see text]-electron HF systems. Here, we present a combined infrared spectroscopy and first-principles band structure calculation study of the [Formula: see text]-electron HF compound YFe[Formula: see text]Ge[Formula: see text]. The infrared response exhibits several charge-dynamical hallmarks of HF and a corresponding scaling behavior that resemble those of the [Formula: see text]-electron HF systems.

Hypoxia-driven heterogeneous expression of α5 integrin in glioblastoma stem cells is linked to HIF-2α.

Despite numerous molecular targeted therapies tested in glioblastoma (GBM), no significant progress in patient survival has been achieved in the last 20 years in the overall population of GBM patients except with TTfield setup associated with the standard of care chemoradiotherapy. Therapy resistance is associated with target expression heterogeneity and plasticity between tumors and in tumor niches. We focused on α5 integrin implicated in aggressive GBM in preclinical and clinical samples.

Composite antiferromagnetic and orbital order with altermagnetic properties at a cuprate/manganite interface.

Heterostructures from complex oxides allow one to combine various electronic and magnetic orders as to induce new quantum states. A prominent example is the coupling between superconducting and magnetic orders in multilayers from high- cuprates and manganites. A key role is played here by the interfacial CuO layer whose distinct properties remain to be fully understood.

The influence of food sensory properties on eating behaviours in children with Down syndrome.

Developing new food products for children is challenging, particularly in vulnerable groups including children with Down syndrome (DS). Focusing on children with DS, the aim of this study was to study the influence of parent liking on acceptance of food products by children with DS and demonstrate the influence of food sensory properties on indicators of food acceptance, food rejection, and challenging eating behaviours. Children (ages 1158 months) with DS (n = 111) participated in a home use test evaluating snack products with varying sensory properties as profiled by a trained sensory panel.

RAPID BRAIN MENINGES SURFACE RECONSTRUCTION WITH LAYER TOPOLOGY GUARANTEE.

The meninges, located between the skull and brain, are composed of three membrane layers: the pia, the arachnoid, and the dura. Reconstruction of these layers can aid in studying volume differences between patients with neurodegenerative diseases and normal aging subjects. In this work, we use convolutional neural networks (CNNs) to reconstruct surfaces representing meningeal layer boundaries from magnetic resonance (MR) images.

Synthesis and Preclinical Fluorescence Imaging of Dually Functionalized Antibody Conjugates Targeting Endothelin Receptor-Positive Tumors.

For the past two decades, the emerging role of the endothelin (ET) axis in cancer has been extensively investigated, and its involvement in several mechanisms described as "hallmarks of cancer" has clearly highlighted its potential as a therapeutic target. Despite the growing interest in finding effective anticancer drugs, no breakthrough treatment has successfully made its way to the market. Recently, our team reported the development of a new immuno-positron emission tomography probe targeting the ET A receptor (ET, one of the ET receptors) that allows the successful detection of ET glioblastoma, paving the way for the elaboration of novel antibody-based strategies.

Glioblastoma Metabolism: Insights and Therapeutic Strategies.

Tumor metabolism is emerging as a potential target for cancer therapies. This new approach holds particular promise for the treatment of glioblastoma, a highly lethal brain tumor that is resistant to conventional treatments, for which improving therapeutic strategies is a major challenge. The presence of glioma stem cells is a critical factor in therapy resistance, thus making it essential to eliminate these cells for the long-term survival of cancer patients.

First Comparison Study of the and Properties of a Randomly and Site-Specifically Conjugated SPECT/NIRF Monomolecular Multimodal Imaging Probe (MOMIP) Based on an aza-BODIPY Fluorophore.

Among all approaches in molecular imaging, the combination of near-infrared fluorescence imaging (NIRF) with radioisotopic imaging (PET or SPECT) allows one to benefit from the advantages of each of the imaging techniques, which are very complementary and of comparable sensitivity. To this end, the construction of monomolecular multimodal probes (MOMIP) has made it possible to combine the two imaging modalities within the same molecule, thus limiting the number of bioconjugation sites and yielding more homogeneous conjugates compared with those prepared through sequential conjugation. However, in order to optimize the bioconjugation strategy and, at the same time, the pharmacokinetic and biodistribution properties of the resulting imaging agent, a site-specific approach may be preferred.

Use of two point-of-care analyzers provides reference intervals of prothrombin time and activated partial prothrombin time in nonanesthetized healthy ferrets (Mustela putorius furo).

Objective: Coagulation tests are an essential tool in the diagnosis and management of coagulopathies in mammals. The aim of the current study was to establish reference intervals for prothrombin time (PT) and activated partial PT (aPTT) in healthy ferrets using 2 different point-of-care analyzers (Idexx Coag DX and MS QuickVet Coag Combo).

Animals: 86 clinically healthy ferrets under 3 years of age (47 females and 39 males) from 4 breeders and 2 private practices.

Analogies of phonon anomalies and electronic gap features in the infrared response of Sr14-xCaCuOand underdoped YBaCuO6+x.

We present an experimental and theoretical study which compares the phonon anomalies and the electronic gap features in the infrared response of the weakly coupled two-leg-ladders in Sr14-xCaCuO(SCCO) with those of the underdoped high-superconductor YBaCuO6+x(YBCO) and thereby reveals some surprising analogies. Specifically, we present a phenomenological model that describes the anomalous doping- and temperature-dependence of some of the phonon features in the-axis response (field along the rungs of the ladders) of SCCO. It assumes that the phonons are coupled to charge oscillations within the ladders.

Polyethylenimine, an Autophagy-Inducing Platinum-Carbene-Based Drug Carrier with Potent Toxicity towards Glioblastoma Cancer Stem Cells.

The difficulty involved in the treatment of many tumours due to their recurrence and resistance to chemotherapy is tightly linked to the presence of cancer stem cells (CSCs). This CSC sub-population is distinct from the majority of cancer cells of the tumour bulk. Indeed, CSCs have increased mitochondrial mass that has been linked to increased sensitivity to mitochondrial targeting compounds.

Clinical and imaging findings, treatment details and outcomes in foals with extensor tendon rupture-A multicentre retrospective study.

Background: Forelimb extensor tendon rupture (ETR) in foals is sparsely documented.

Objectives: To describe clinical and imaging findings, treatment details, and long-term outcome in foals with ETR.

Study Design: Multicentre retrospective case-series.

Eating behaviors in children with Down syndrome: Results of a home-use test.

Children with Down syndrome (DS) display a disproportionate number of health challenges, including feeding and swallowing difficulties and food texture sensitivities. To start addressing food texture challenges early in life, the aim of this research was to understand mealtime behaviors and identify preferred food textures of children with DS. Children (aged 11 to 58 months) with DS (n = 111) and without (typically developing, TD; n = 107) participated in a home use test evaluating snack products of varying textures.

Site-Specific, Platform-Based Conjugation Strategy for the Synthesis of Dual-Labeled Immunoconjugates for Bimodal PET/NIRF Imaging of HER2-Positive Tumors.

Because positron emission tomography (PET) and optical imaging are very complementary, the combination of these two imaging modalities is very enticing in the oncology field. Such bimodal imaging generally relies on imaging agents bearing two different imaging reporters. In the bioconjugation field, this is mainly performed by successive random conjugations of the two reporters on the protein vector, but these random conjugations can alter the vector properties.

Adapting to the pandemic: longitudinal effects of social restrictions on time perception and boredom during the Covid-19 pandemic in Germany.

With the Covid-19 pandemic, many governments introduced nationwide lockdowns that disrupted people's daily routines and promoted social isolation. We applied a longitudinal online survey to investigate the mid-term effects of the mandated restrictions on the perceived passage of time (PPT) and boredom during and after a strict lockdown in Germany. One week after the beginning of the lockdown in March 2020, respondents reported a slower PPT and increased boredom compared to the pre-pandemic level.

Temozolomide-Acquired Resistance Is Associated with Modulation of the Integrin Repertoire in Glioblastoma, Impact of α5β1 Integrin.

Despite extensive treatment, glioblastoma inevitably recurs, leading to an overall survival of around 16 months. Understanding why and how tumours resist to radio/chemotherapies is crucial to overcome this unmet oncological challenge. Primary and acquired resistance to Temozolomide (TMZ), the standard-of-care chemotherapeutic drug, have been the subjects of several studies.

Wider is better but sharper is not: optimizing the image of camera-monitor systems.

The replacement of rear-view mirrors with camera-monitor systems introduces new opportunities for design, such as altering the image quality and the rearward field-of-view. We investigated how the image quality and field-of-view might affect the distance and time-to-contact estimation of other vehicles. Eighty-six subjects estimated either their egocentric distance to a stationary vehicle (Experiment I) or the time-to-contact to an approaching vehicle (Experiment II).

Estimating time-to-contact when vision is impaired.

Often, we have to rely on limited information when judging time-to-contact (TTC), as for example, when driving in foul weather, or in situations where we would need reading glasses but do not have them handy. However, most existing studies on the ability to judge TTC have worked with optimal visual stimuli. In a prediction motion task, we explored to what extent TTC estimation is affected by visual stimulus degradation.

Development and application of specific questions to classify a child as food texture sensitive.

Understanding food texture sensitivity in children is important in guiding food selection. The objective of this work was to develop a short questionnaire that could be completed by parents in nonclinical settings to provide a categorization for food texture sensitivity in children. This study evaluated the distribution of children as texture sensitive (TS) or non-texture sensitive (NTS) and the predictive validity of these questions to explain rejection of specific food textures.

Label-Free Study of Protein Adsorption on Nanoparticles.

Improving the design of nanoparticles for use as drug carriers or biosensors requires a better understanding of the protein-nanoparticle interaction. Here, we present a new tool to investigate this interaction and without additional labeling of the proteins and/or nanoparticles. By combining nonresonant second-harmonic light scattering with a modified Langmuir model, we show that it is possible to gain insight into the adsorption behavior of blood proteins, namely fibrinogen, human serum albumin, and transferrin, onto negatively charged polystyrene nanoparticles.

Physical distancing and the perception of interpersonal distance in the COVID-19 crisis.

In the wake of the COVID-19 pandemic, it has been mandated to keep enlarged distances from others. We interviewed 136 German subjects over five weeks from the end of March to the end of April 2020 during the first wave of infections about their preferred interpersonal distance (IPD) before, during, and after the COVID-19 pandemic. In response to the pandemic, subjects adapted to distance requirements and preferred a larger IPD.

Total Angular Momentum Dichroism of the Terahertz Vortex Beams at the Antiferromagnetic Resonances.

Terahertz vortex beams with different superposition of the orbital angular momentum l=±1, ±2, ±3, and ±4 and spin angular momentum σ=±1 were used to study antiferromagnetic (AFM) resonances in TbFe_{3}(BO_{3})_{4} and Ni_{3}TeO_{6} single crystals. In both materials we observed a strong vortex beam dichroism for the AFM resonances that are split in external magnetic field. The magnitude of the vortex dichroism is comparable to that for conventional circular dichroism due to σ.