Optimizing CAR-T treatment: A TEVOLVE guide to raw and starting material selection.

Chimeric antigen receptor (CAR)-T cell products, classified as Advanced Therapy Medicinal Products (ATMPs), have shown promising outcomes in cancer immunotherapy. The quality of raw and starting materials used in manufacturing is critical to ensure the efficacy and safety of CAR-T cell products and depends primarily on the selection of the right materials and the right suppliers. It is essential to consider a long-term strategy when selecting raw and starting materials to prevent delays in the supply of innovative, high-quality, and safe therapies to patients.

Bilateral pediatric cataract surgery: outcomes of 390 children from Nepal and Northern India.

Purpose: To report the outcomes of bilateral pediatric cataract surgery from eastern Nepal and northern India.

Methods: Preoperative, intraoperative, and postoperative data of 390 children who underwent surgery bilaterally between 2007 and 2009 were analyzed.

Results: Forty-two (10.

Myeloperoxidase deficiency preserves vasomotor function in humans.

Aims: Observational studies have suggested a mechanistic link between the leucocyte-derived enzyme myeloperoxidase (MPO) and vasomotor function. Here, we tested whether MPO is systemically affecting vascular tone in humans.

Methods And Results: A total of 12 135 patients were screened for leucocyte peroxidase activity.

Electrophysiological characterization of chloride secretion across the jejunum and colon of pigs as affected by age and weaning.

Hypersecretion of chloride can cause diarrhea, a disease frequently occurring in young pigs, particularly around weaning. We investigated the contribution of different channels to intestinal Cl(-) secretion as influenced by age and weaning. Jejunal and colonic epithelia from 4-month-old pigs and 4-week-old piglets were incubated in Ussing chambers and stimulated by carbachol and forskolin.

Effect of central corneal thickness and corneal hysteresis on tonometry as measured by dynamic contour tonometry, ocular response analyzer, and Goldmann tonometry in glaucomatous eyes.

Purpose: The dynamic contour tonometer (DCT; Pascal tonometer) and the Ocular Response Analyzer (ORA) are novel tonometers designed to measure intraocular pressure (IOP) independent of corneal properties and central corneal thickness (CCT), respectively. We wanted to compare the corneal compensated IOP (IOPcc) as measured by ORA with IOP values measured by DCT and Goldmann applanation tonometry (GAT) with respect to IOP readings and the influence of corneal hysteresis (CH) and CCT in glaucoma patients.

Patients And Methods: In a study of 94 glaucomatous eyes, IOP measurements by ORA, DCT, and GAT were compared, and the effects of CCT and CH were analyzed.

Changes in corneal hysteresis after clear corneal cataract surgery.

Purpose: To assess the changes in corneal hysteresis (CH) as measured by the Ocular Response Analyzer (ORA; Reichert Ophthalmic Instruments, Buffalo, New York, USA) to describe the influence of clear corneal cataract surgery on corneal viscoelastic properties and intraocular pressure (IOP) measured by noncontact tonometry (NCT) and Goldmann applanation tonometry (GAT).

Design: Retrospective, interventional, comparative study.

Methods: One hundred and one eyes of 101 consecutive patients who underwent routine clear corneal cataract surgery were evaluated.

Effect of orally administered probiotic E. coli strain Nissle 1917 on intestinal mucosal immune cells of healthy young pigs.

Several beneficial effects of probiotics have been described in studies using rodent disease models and in human patients; however, the underlying mechanisms remained mostly unclear. Only a few studies focused on the effects of probiotics on the intestinal mucosal immune system. Here, we studied the effect of the probiotic strain E.

Quantification of recti eye muscle paths in high myopia.

Purpose: To elucidate the etiology of an acquired, restrictive motility disorder in patients with high myopia.

Methods: Thirty-three orbits were imaged using a Siemens Magnetom or Siemens Vision (both 1.5 Tesla) MRI (magnetic resonance imaging) scanner, applying a head coil.

[The predictive value of a classification for proliferative diabetic vitreoretinopathy].

Background: Kroll's classification of proliferative diabetic vitreoretinopathy (PDVR) defines stage A (vitreoretinal proliferations without retinal detachment), stage B (partially detached retina not involving the macula), stage C (partially detached macula) and stage D (completely detached macula). The purpose of this study was to analyse the prognostic value of Kroll's classification in respect of the postoperative results of vitreoretinal surgery based on our group of patients.

Patients And Methods: The charts of 563 patients who underwent vitrectomy because of PDVR between 1990 and 1997 were examined retrospectively.