Long-term results after microsurgery for Cushing disease: experience with 426 primary operations over 35 years.

Objectives: The aim of this paper was to demonstrate the long-term results following microsurgery in a single surgeon's continuous series of patients with Cushing disease (CD), to assess the influence of changes in surgical procedures, and to compare the results with those of other treatment modalities. In particular, preoperative diagnosis, tumor size, results of histological examination, and complications were considered.

Methods: Between 1971 and 2004, 426 patients suffering from newly diagnosed CD underwent primary surgery.