[Treatment of diabetic ketoacidosis in children].

Two groups of children with severe diabetic ketoacidosis were treated with 2 different insulin regimens: the first with conventional intermittent intramuscular insulin injections (0.5-1.0 U/kg/3-4 hrs), the second, with continuous low-dose insulin infusion (0.

[Concentrated radiotherapy of brain metastases].

Presentation of 60 patients with cerebral metastases irradiated with a telecobaltotherapy machine (concentrated high dose treatment) from 1976 to 1979; 47 patients fully completed the treatment: 11 patients had only one part of the concentrated treatment and 36 patients had both parts of the concentrated treatment. Of the 11 patients who received only one part of the concentrated high dose treatment (3 x 650 rads mid-line dose to the whole brain during 3 consecutive days and then, after a rest period of 3 weeks, 12 x 170 rads mid-line dose given in two weeks using classical fractionation, total dose 3990 rads), 9 (81.8%) responded favourably with average survival of 5 months.

Adjuvant chemotherapy with procarbazine, vincristine and prednisone for medulloblastomas. A preliminary report.

The survival of 20 children with medulloblastoma who received adjuvant chemotherapy with procarbazine, vincristine and prednisone after resection and craniospinal irradiation is compared with the preliminary results of the Children's Cancer Study Group (CCSG) and the international Society of Pediatric Oncology (SIOP) medulloblastoma studies. Survival with the chemotherapy used in the SPOG study ws not superior to the survival of children who received craniospinal irradiation only.

[Detection of coeliac disease in the late childhood. Discussion on clinical presentation and diagnostic criteria. (Preliminary results) (author's transl)].

In this study 9 children ranging from 8 to 15 years of age affected by "short stature" not due to endocrine diseases underwent intestinal biopsy. In 5 of then a subtotal villous athrophy (STVA) has been shown and coeliac disease then diagnosed. The AA.

[Treatment by human chorionic gonadotropin in maldescended testes. (Synthesis of our experience)].

87 prepuberal children, 2-15 years old, 58 with unilateral and 29 with bilateral cryptorchidism, were treated intramuscularly with Human Chorionic Gonadotropin (HCG). HCG was administered in 16 children in single dose (5.000 IU/m2), in 11 children every other day for one week (3 x 1,500 IU) and in 60 children twice a week (2 x 1,000 IU) for 3-7 weeks.

Effect of chloro-N-desmethyldiazepam on serum and brain tryptophan and serotonin in relation to the activity of central serotonergic neurons.

Chloro-N-desmethyldiazepam (CDD) significantly reduced plasma tryptophan (TRY) and increased brain TRY in mice and rats. Quipazine did not change TRY levels in mouse plasma and brain but it respectively reduced and increased these two parameters in rats, to almost the same extent as CDD. Metergoline, an antagonist of serotonergic receptors, decreased blood TRY in both mice and rats but failed to change brain TRY.

[Premature thelarche and precocious puberty. Clinical findings and endocrinological data useful for differential diagnosis].

Clinical features, urocytogram and gonadotropin response to LHRH (100 microgram/1,73 m2 i.v.) were evaluated in 10 girls with premature thelarche and 4 girls with precocious puberty to purpose to describe the differences between the two diseases.

p-Chlorophenylalanine-induced muricidal aggression in male and female laboratory rats.

p-Chlorophenylalanine (pCPA), a potent inhibitor of serotonin synthesis, specifically depletes brain serotonin in a dose-dependent manner. The resulting impairment of serotonergic inhibitory control of the brain is considered responsible for the consequent muricidal aggression that arises in pCPA-treated rats independent of their strain-dependent genetic predisposition and sex propensity to display this behavior. Judging from the data obtained, the minimal impairment of serotonergic inhibitory control required to induce consistent muricidal aggression in rats of both sexes of the strains considered, corresponds to a brain serotonin depletion of about 55-60%.

Neurochemical correlates of muricidal behavior in rats.

Surgical, pharmacological or environmental manipulation are widely employed to induce muricidal behavior in naive laboratory male rats. The genetic predisposition of an animal strain to kill mice remains, however, an important factor to obtain the muricidal reaction. Data from the pertinent literature suggest that muricidal behavior may possibly be sustained by increased dopaminergic or catecholaminergic activity in the presence of reduced serotoninergic activity.

The Cohen syndrome: clinical and endocrinological studies of two new cases.

This report concerns two new cases of the Cohen syndrome and gives further information on the variable phenotypical pattern of the disease. The frequency of major and minor clinical signs is reviewed from all the published reports. Among the minor signs we found previously undescribed skeletal abnormalities in one of our patients.

[Leydig cell function in cryptorchid boys (author's transl)].

Testicular endocrine function was assessed in 54 cryptorchid boys, 9 of whom had previously been treated with human chorionic gonadotrophin (HCG). Two different HCG tests were used, the first being short (5,000 IU/m2) and the second more prolonged (3 x 1,500 IU). The testosterone response to the two tests is both quantitatively and qualitatively different.

[Results of radio-surgical treatment of primary malignant lymphomas of the digestive tract].

In 29 patients treated in the Department of radiotherapy of the University Hospital, Lausanne, between 1963 to 1978, 18 of these lesions were localized in the stomach (1 was confined to the oesophago-gastric region), 10 in the small intestine and 1 in the rectum. The patients comprised 18 men and 11 women; the majority (21 out of 29) were over 50 years of age. Using the former histological classification, 13 patients had lymphomas of the lymphocytic type (in which 1 was a Brill-Symmers), 13 had reticulum cell sarcomas and 3 had mixed type.

[Solitary maxillary central incisor with growth hormone deficiency (author's transl)].

A prepubertal girl with growth hormone deficiency and a solitary maxillary central incisor is described. The association of these two abnormalities can be explained by a single embryological defect.

Effects of human growth hormone on blood polyamines in hypopituitarism.

Blood levels of polyamines were evaluated in hypopituitary patients after i.m. injection of human growth hormone (hGH).