Publications by authors named "Bernardo Sbarro"
Br J Pharmacol
April 2022
Article Synopsis
- N-Acylethanolamine acid amidase (NAAA) is crucial for breaking down certain compounds and its inhibition has potential benefits in treating inflammatory diseases and now, colorectal cancer (CRC).
- In preclinical models, the NAAA inhibitor AM9053 significantly reduced CRC tumor growth and altered the tumor secretome, suggesting that NAAA plays a role in tumor progression through specific molecular pathways.
- Findings indicate that NAAA could serve as a promising drug target for CRC treatment, as its inhibition impacted cell growth and cycle regulation in cancer cells, with reduced expression noted in human CRC samples.
