Publications by authors named "Bernardo F Spiazzi"
Article Synopsis
- This study evaluated the impact of SGLT2 inhibitors on heart-related health outcomes and mortality rates, focusing on different kidney disease risk groups (KDIGO and UACR).
- Researchers analyzed data from 14 large randomized trials involving over 97,000 participants and found that SGLT2 inhibitors significantly reduced major cardiovascular events and all-cause mortality, with particular benefits noted in high-risk kidney disease groups.
- The findings suggest that SGLT2 inhibitors can improve cardiovascular health, especially in patients with severe kidney disease.
Background: SGLT2 inhibitors have shown to reduce clinically meaningful kidney outcomes in individuals with chronic kidney disease at high risk for adverse outcomes. The effect of these agents in preventing clinically meaningful kidney outcomes in populations at lower risk remain uncertain. We aim to evaluate the effect of SGLT2 inhibitors on kidney outcomes across the Kidney Disease: Improving Global Outcomes (KDIGO) classification and urinary albumin-to-creatinine ratio (UACR) levels.
View Article and Find Full Text PDFAim: To evaluate the effect of metformin on cancer incidence in subjects with overweight/obesity and/or prediabetes/diabetes.
Materials And Methods: We searched MEDLINE, Embase and CENTRAL for randomized controlled trials (RCTs) in adults with overweight/obesity and/or prediabetes/diabetes that compared metformin to other interventions for ≥24 weeks. Independent reviewers selected and extracted data including population and intervention characteristics and new diagnoses of cancer.
Recent data from meta-analyses of randomized clinical trials (RCTs) suggest that dietary intake of coconut oil, rich in saturated fatty acids, does not result in cardiometabolic benefits, nor in improvements in anthropometric, lipid, glycemic, and subclinical inflammation parameters. Nevertheless, its consumption has surged in recent years all over the world, a phenomenon which can possibly be explained by an increasing belief among health professionals that this oil is as healthy as, or perhaps even healthier than, other oils, in addition to social network misinformation spread. The objective of this review is to present nutritional and epidemiological aspects related to coconut oil, its relationship with metabolic and cardiovascular health, as well as possible hypotheses to explain its high rate of consumption, in spite of the most recent data regarding its actual effects.
View Article and Find Full Text PDFResponse to Letter to the Editor From Stumpf et al: Cancer Outcomes Among Prediabetes and Type 2 Diabetes Populations With Dietary and Physical Activity-Based Lifestyle Interventions.
J Clin Endocrinol Metab
October 2023
Aims: Concerns regarding breast and bladder cancer risk with Sodium-glucose cotransporter-2 (SGLT2) inhibitors remain controversial and its effect on cancer mortality is unknown. We aim to evaluate the association between SGLT2 inhibitors and the risk of cancer outcomes.
Methods: We searched PubMed, Embase and CENTRAL up to June 20th, 2022, for randomized controlled trials of SGLT2 inhibitors in adults, with a minimum follow-up of 48 weeks.
Context: People with type 2 diabetes (T2D) have higher risks of cancer incidence and death.
Objective: We aimed to evaluate the relationship between dietary and physical activity-based lifestyle intervention and cancer outcomes among prediabetes and T2D populations.
Methods: We searched for randomized controlled trials with at least 24 months of lifestyle interventions in prediabetes or T2D populations.
Background: Despite having a 92% concentration of saturated fatty acid composition, leading to an apparently unfavorable lipid profile, body weight and glycemic effect, coconut oil is consumed worldwide. Thus, we conducted an updated systematic review and meta-analysis of randomized clinical trials (RCTs) to analyze the effect of coconut oil intake on different cardiometabolic outcomes.
Methods: We searched Medline, Embase, and LILACS for RCTs conducted prior to April 2022.
Background And Aims: Despite recent scientific evidence indicating absence of cardiometabolic benefit resulting from coconut oil intake, its consumption has increased in recent years, which can be attributed to a promotion of its use on social networks. We evaluated the patterns, reasons and beliefs related to coconut oil consumption and its perceived benefits in an online survey of a population in southern Brazil.
Methods And Results: We conducted a before-and-after study using an 11-item online questionnaire that evaluated coconut oil consumption.
Context: Risk of cancer is a major concern in the development of drugs for the treatment of obesity and diabetes. In randomized controlled trials (RCTs) of the Liraglutide Clinical Development Program, subjects treated with a glucagon-like peptide-1 receptor agonist (GLP-1RA) had a higher absolute number of breast cancer events.
Objective: To assess whether patients treated with GLP-1RAs had a higher risk of breast neoplasms.