Publications by authors named "Bernardo Da Silva"

Article Synopsis
  • Human Herpesviruses (HHVs) are linked to serious neurological diseases like encephalitis and meningitis, presenting a major health challenge, especially for individuals with compromised immune systems such as those with HIV/AIDS.
  • A study of 895 patients suspected of having viral CNS infections found that 7.5% tested positive for HHVs, with Cytomegalovirus (HCMV) and Epstein-Barr Virus (EBV) being the most common, emphasizing their role in neurological conditions.
  • The findings highlight the importance of analyzing cerebrospinal fluid (CSF) for accurate diagnosis and stress the need for tailored treatment strategies in managing CNS infections, particularly in immunocompromised patients.
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To verify if data obtained in the prehospital evaluation of patients with severe acute respiratory syndrome (SARS) during the initial response to the COVID-19 pandemic is associated with clinical outcomes: mechanical ventilation, hospital discharge, and death. This is a retrospective analysis involving secondary data from the Emergency Medical Service (EMS) records and the Health Surveillance Information System of patients assisted by the EMS in Manaus, from January to June 2020, the period of the first peak of COVID-19 cases. The combination of the two databases yielded a total of 1.

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Objective: This study aimed to present a temporal and spatial analysis of the 2018 measles outbreak in Brazil, particularly in the metropolitan city of Manaus in the Amazon region, and further introduce a new tool for spatial analysis.

Methods: We analyzed the geographical data of the residences of over 7,000 individuals with measles in Manaus during 2018 and 2019. Spatial and temporal analyses were conducted to characterize various aspects of the outbreak, including the onset and prevalence of symptoms, demographics, and vaccination status.

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Article Synopsis
  • The study investigates the relationship between dynapenia (loss of muscle strength) and functional limitations in long COVID patients, suggesting that muscle strength may contribute to the ongoing challenges faced by these individuals.
  • Out of 113 patients assessed 120 days post-severe COVID-19, 22% were found to have dynapenia, correlating with lower muscle mass, respiratory function, and exercise capacity compared to non-dynapenic peers.
  • The findings indicate that measuring hand-grip strength (HGS) is an effective, cost-efficient way to gauge functional impairment in long COVID patients, potentially serving as a useful tool in clinics, particularly in less affluent areas.
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Introduction: Chronic plantar ulcers in leprosy are lesions resulting from motor and sensory alterations caused by Mycobacterium leprae. They are lesions refractory to conventional dressings and present high recurrence rates.

Objective: To evaluate the epidemiological clinical profile of patients with chronic plantar ulcers associated with bony prominences in the lesion bed and to evaluate the efficacy of orthopedic surgical treatment of these lesions.

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Article Synopsis
  • - This study aimed to investigate healthcare disparities in pulmonary embolism (PE) among Hispanic and Latino patients, who are often underrepresented in research related to this condition.
  • - The analysis, involving 1,265 PE cases from 2013 to 2019, found that Hispanic or Latino patients presented with less severe PE and had lower intervention rates, but similar inpatient mortality compared to non-Hispanic patients.
  • - The findings suggest that while Hispanic or Latino patients experience less severe PE, further research is necessary to understand the underlying factors affecting their in-hospital care and outcomes.
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Introduction: In chronic kidney disease (CKD) patients, the risk of kidney replacement therapy (KRT) is highly variable. In 2011, Tangri et al. developed the kidney failure risk equations (KFRE) to predict the 2 and 5-year probability of requiring kidney replacement therapy (KRT).

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Globally, malaria and human immunodeficiency virus (HIV) are both independently associated with a massive burden of disease and death. While their co-infection has been well studied for Plasmodium falciparum, scarce data exist regarding the association of P. vivax and HIV.

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The spatio-temporal assessment of water and carbon fluxes in Brazil's Northeast region (NEB) allows for a better understanding of these surface flux patterns in areas with different vegetation physiognomies. The NEB is divided into four biomes: Amazon, Cerrado, Caatinga, and Atlantic Forest. Land degradation is a growing problem, particularly in susceptible areas of the Caatinga biome, such as the seasonally dry tropical forest.

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Background And Aims: Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) associated acute liver injury (ALI) has been linked to poor outcomes in adults. Here we compare characteristics in children with elevated ALT (E-ALT) in two distinct manifestations of the infection, multisystem inflammatory syndrome-children (MIS-C) and coronavirus disease 2019 (COVID-19).

Methods: This is a retrospective study of patients ≤21 years of age with positive for SARS-CoV-2 PCR.

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Article Synopsis
  • Cancer is the second leading cause of death worldwide, with a high percentage of advanced patients suffering from significant pain, and limited options for chronic pain management.
  • Esketamine, a newer drug with better analgesic effects and fewer side effects than traditional opioids, has been FDA-approved for depression but never tested for chronic cancer pain.
  • A proposed phase II trial will test intranasal esketamine in 120 participants with chronic opioid refractory pain to assess its effectiveness and safety, aiming to improve pain management and quality of life.
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Background: Malaria and HIV are two important public health issues. However, evidence on HIV-Plasmodium vivax co-infection (HIV/PvCo) is scarce, with most of the available information related to Plasmodium falciparum on the African continent. It is unclear whether HIV can change the clinical course of vivax malaria and increase the risk of complications.

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Background And Aims: A newly recognized multisystem inflammatory syndrome in children (MIS-C) has had a paradigm-shifting effect on the perception of severe acute respiratory syndrome, coronavirus-2 (SARS-CoV-2) illness severity in children. We report the clinical and biochemical features of liver involvement, and the comorbidities that present with hepatitis, in a substantial cohort of patients.

Approach And Results: This is a retrospective cohort study of 44 patients with MIS-C admitted at Morgan Stanley Children's Hospital of New York-Presbyterian during April and May 2020.

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Arid and semi-arid environments correspond to one-third of the Earth's terrestrial surface. In these environments, precipitation is an essential and limiting element for vegetation growth and ecosystem biomass productivity. The semi-arid region of Brazil comprises around 11.

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Objective: To compare the long-term efficacy of Young-Dees bladder neck reconstruction (YDBNR) alone versus YDBNR plus bladder neck injection (BNI) in patients with urinary incontinence caused by urethral sphincter insufficiency.

Patients And Methods: Between 1987 and 2006, we assessed the continence rates obtained with YDBNR and BNI as a supplementary treatment for persistent outlet insufficiency in patients with neurogenic bladder (group 1, n = 35) and bladder exstrophy (group 2, n = 20). Median postoperative follow-up was 16 years (range: 5-29).

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