A Comparative Review of the SWEET Simulator: Theoretical Verification Against Other Simulators.

Accurate luminance-based image generation is critical in physically based simulations, as even minor inaccuracies in radiative transfer calculations can introduce noise or artifacts, adversely affecting image quality. The radiative transfer simulator, SWEET, uses a backward Monte Carlo approach, and its performance is analyzed alongside other simulators to assess how Monte Carlo-induced biases vary with parameters like optical thickness and medium anisotropy. This work details the advancements made to SWEET since the previous publication, with a specific focus on a more comprehensive comparison with other simulators such as Mitsuba.

Metformin impacts the differentiation of mouse bone marrow cells into macrophages affecting tumour immunity.

Background: Epidemiological studies suggest that metformin reduces the risk of developing several types of cancer, including gliomas, and improves the overall survival in cancer patients. Nevertheless, while the effect of metformin on cancer cells has been extensively studied, its impact on other components of the tumour microenvironment, such as macrophages, is less understood.

Results: Metformin-treated mouse bone marrow cells differentiate into spindle-shaped macrophages exhibiting increased phagocytic activity and tumour cell cytotoxicity coupled with modulated expression of co-stimulatory molecules displaying reduced sensitivity to inflammatory cues compared with untreated cells.

The 68 symptoms of the clinical high risk for psychosis: Low similarity among fourteen screening questionnaires.

The Clinical High Risk for psychosis (CHR) is a heterogeneous condition with multiple symptoms. CHR screening is challenging in routine care, as a wide variety of questionnaires exists. We propose to explore the extent to which these questionnaires differ or overlap in item content.

Cross-Talk between miRNAs from the Dlk1-Dio3 Locus and Histone Methylation to Protect Male Cerebellum from Methyl Donor Deficiency.

Scope: Disruption of the one carbon metabolism during development, i.e., following a gestational vitamin B9 and B12 deficiencies, is involved in birth defects and brain development delay.

Association between retinal and cortical visual electrophysiological impairments in schizophrenia.

Background: Electrophysiological impairments in the magnocellular visual system have been reported among patients with schizophrenia, but previous theories proposed that these deficits may begin in the retina. We therefore sought to evaluate the potential contribution of the retina by comparing retinal and cortical visual electrophysiological impairments between patients with schizophrenia and healthy controls.

Methods: We recruited patients with schizophrenia and age- and sex-matched healthy controls.

Quantification of 782 Plasma Peptides by Multiplexed Targeted Proteomics.

Blood analysis is one of the foundations of clinical diagnostics. In recent years, the analysis of proteins in blood samples by mass spectrometry has taken a jump forward in terms of sensitivity and the number of identified proteins. The recent development of parallel reaction monitoring with parallel accumulation and serial fragmentation (prm-PASEF) combines ion mobility as an additional separation dimension.

Bronchoscopic findings in dogs with bronchial vegetal foreign bodies: 84 cases (2010-2020).

Objectives: To describe endoscopic findings, foreign body location, success rate of removal and complications in dogs with bronchial vegetal foreign bodies.

Materials And Methods: The current study retrospectively evaluated the case records of dogs diagnosed with bronchial vegetal foreign bodies at a veterinary hospital centre between January 2010 and April 2020. Information retrieved included breed, sex, age, bodyweight, the season of presentation, presentation and duration of clinical signs, previous removal attempts performed by the referring veterinarian, foreign body location and endoscopic and imaging findings.

SWEET: A Realistic Multiwavelength 3D Simulator for Automotive Perceptive Sensors in Foggy Conditions.

Improving the reliability of automotive perceptive sensors in degraded weather conditions, including fog, is an important issue for road safety and the development of automated driving. Cerema has designed the PAVIN platform reproducing fog and rain conditions to evaluate optical automotive sensor performance under these conditions. In order to increase the variety of scenarios and technologies under test, the use of digital simulation becomes a major asset.

Analysis of Thermal Imaging Performance under Extreme Foggy Conditions: Applications to Autonomous Driving.

Object detection is recognized as one of the most critical research areas for the perception of self-driving cars. Current vision systems combine visible imaging, LIDAR, and/or RADAR technology, allowing perception of the vehicle's surroundings. However, harsh weather conditions mitigate the performances of these systems.

Visual electrophysiology and neuropsychology in bipolar disorders: A review on current state and perspectives.

Bipolar disorder is a lifelong condition. Today, there is a urgent need to find indicators of the disease. Specifically, they could be useful to improve the diagnosis and the early detection, the prognosis, to estimate the treatment response and to create homogeneous subgroups of patients based on similar pathophysiological mechanisms.

Allergen Content of Therapeutic Preparations for Allergen-Specific Immunotherapy of European Paper Wasp Venom Allergy.

Allergy to (European paper wasp) venom is of particular relevance in Southern Europe, potentially becoming a threat in other regions in the near future, and can be effectively cured by venom immunotherapy (VIT). As allergen content in extracts may vary and have an impact on diagnostic and therapeutic approaches, the aim was to compare five therapeutic preparations for VIT of venom allergy available in Spain. Products from five different suppliers were analyzed by SDS-PAGE and LC-MS/MS and compared with a reference venom sample.

Enzymatic activity of glycosyltransferase GLT8D1 promotes human glioblastoma cell migration.

Glioblastoma (GBM) is the most aggressive primary brain tumor characterized by infiltrative growth of malignant glioma cells into the surrounding brain parenchyma. In this study, our analysis of GBM patient cohorts revealed a significantly higher expression of 8 () compared to normal brain tissue and could be associated with impaired patient survival. Increased expression of significantly enhanced migration of two different sphere-forming GBM cell lines.

Altered central vision and amacrine cells dysfunction as marker of hypodopaminergic activity in treated patients with schizophrenia.

Background: Retinal dysfunction is widely documented in schizophrenia using flash (fERG) and pattern electroretinograms (PERG), but the role of dopamine transmission has seldom been explored.

Methods: We explored the role of dopamine transmission by evaluating the spatial location of retinal anomalies using multifocal ERG (mfERG) in photopic condition and the oscillatory potentials (OPs) extracted from fERG measured in scotopic condition in 29 patients with schizophrenia and 29 healthy controls.

Results: With the mfERG, our main results revealed reduced amplitudes in the center of the retina: P1 (p < .

Impaired P100 among regular cannabis users in response to magnocellular biased visual stimuli.

Regular cannabis using causes vision impairment by affecting human retinal neurotransmission. However, studies less considered its impact on the subsequent visual cortical processing, key feature for the integration of the visual signal in brain. We aimed at investigating this purpose in regular cannabis users using spatial frequencies and temporal frequencies filtered visual stimuli.

Treatment and outcome of spontaneous pneumothorax secondary to suspected migrating vegetal foreign body in 37 dogs.

Background: The aim of this study is to describe surgical findings, treatment and outcome of spontaneous pneumothorax (SP) secondary to suspected migrating vegetal foreign body (MVFB).

Methods: This retrospective study included dogs with computed tomography (CT) consistent with SP suspected to be secondary to MVFB that underwent thoracic surgery. They were divided into two groups according to whether CT identified (group 1) or only suspected (group 2) an MVFB.

Assessment of neuropsychological impairments in regular cannabis users.

Background: Cannabis is the most widely used illicit drug in the world. It is responsible for cognitive dysfunction of memory, speed of information processing, attention, and executive functions. Cognitive performance depends on the level of study, tolerance, and duration of abstinence from cannabis use.

Computed tomography may be helpful in discriminating grass awn foreign body rhinitis from non-foreign body rhinitis in dogs.

Grass awn foreign bodies are a common cause of rhinitis in dogs.  Early detection and complete removal of these foreign bodies are important for minimizing risks of long term complications. The objective of this retrospective, descriptive cross-sectional study was to determine whether discriminating CT findings exist between dogs with grass awn foreign body rhinitis and dogs with non-foreign body rhinitis.

Delayed on- and off-retinal responses of cones pathways in regular cannabis users: An On-Off flash electroretinogram case-control study.

The retina is considered a useful area for investigating synaptic transmission abnormalities in neuropsychiatric disorders, including as a result of using cannabis, the most widely consumed illicit substance in the developed world. The impact of regular cannabis use on retinal function has already been evaluated, using pattern and flash electroretinogram (ERG) to demonstrate a delay in ganglion and bipolar cell response. Using multifocal ERG, it was showed that the delay to be preferentially located in the central retina.

Retinal ganglion cell dysfunction is correlated with disturbed visual cognition in schizophrenia patients with visual hallucinations.

Patients with schizophrenia have altered visual cognition and retinal functions. No studies have explored if retinal anomalies are related to visual cognition and the presence of visual hallucinations (VH). We explored functional responses of the retinal ganglion cells in schizophrenia patients with or without VH and conducted a neuropsychological evaluation to explore the links between cognition and retinal function.

Retinal dysfunctions in a patient with a clinical high risk for psychosis and severe visual disturbances: A single case report.

Aim: Psychosis can be preceded by a clinical high risk for psychosis (CHR) and visual anomalies are predictors of transition to psychosis. Visual retinal processing is altered in psychosis, but no study has explored the links between visual symptoms and retinal functions in CHR patients. We report here the case of NR, an antipsychotic-naive young adult with CHR and severe visual symptoms in whom we explored the retinal function.

Highly Multiplexed Targeted Proteomics Acquisition on a TIMS-QTOF.

Targeted proteomics allows the highly sensitive detection of specific peptides and proteins in complex biological samples. Here, we describe a methodology for targeted peptide quantification using a trapped ion mobility quadrupole time-of-flight mass spectrometer (timsTOF Pro). The prm-PASEF method exploits the multiplexing capability provided by the trapped ion mobility separation, allowing more than 200 peptides to be monitored over a 30 min liquid chromatography separation.

Identification of a Blood-Based Protein Biomarker Panel for Lung Cancer Detection.

Lung cancer is the deadliest cancer worldwide, mainly due to its advanced stage at the time of diagnosis. A non-invasive method for its early detection remains mandatory to improve patients' survival. Plasma levels of 351 proteins were quantified by Liquid Chromatography-Parallel Reaction Monitoring (LC-PRM)-based mass spectrometry in 128 lung cancer patients and 93 healthy donors.

Shedding Light on the Venom Proteomes of the Allergy-Relevant Hymenoptera (European Paper Wasp) and spp. (Yellow Jacket).

Allergic reactions to stings of Hymenoptera species can have serious or even fatal consequences. If the identification of the culprit insect is possible, venom-specific immunotherapy effectively cures Hymenoptera venom allergies. Although component-resolved diagnostics has strongly evolved in recent years, the differentiation between allergies to closely related species such as and spp.