Publications by authors named "Bernardes M"

Chronic inflammatory demyelinating polyneuropathy (CIDP) is an acquired, autoimmune peripheral neuropathy, rarely reported as being associated with systemic lupus erythematous (SLE). We report the case of 53-year-old women with a long history of SLE, diagnosed with CIDP during a lupus flare beginning with progressive muscle weakness of lower and upper limbs, without affection of the central nervous system. She received treatment with steroids, intravenous immunoglobulins and anifrolumab and showed clinical and immunological improvement.

View Article and Find Full Text PDF

Objectives: to analyze the social representations of patients with cancer regarding oncologic surgery.

Methods: a qualitative study based on Social Representation Theory was conducted with 126 participants between October 2021 and May 2022 in a public hospital in Rio de Janeiro. A characterization questionnaire, free evocations of the inducing term "surgery", and semi-structured interviews with 60 participants were applied.

View Article and Find Full Text PDF

Hemangiomas are benign congenital vascular tumors that commonly arise in the head and neck regions. Although they present with indolent growth and involution in most cases, they can cause facial deformities. Hemangiomas have three subtypes: capillary, cavernous, and mixed.

View Article and Find Full Text PDF

Background: Synovial chondromatosis is a proliferative disease of the synovium associated with cartilage metaplasia that causes localized joint pain and affects its function.

Case Presentation: A 63-year-old white woman presented with right hip pain, lasting over 10 years. Pelvic radiography showed right hip osteoarthritis and ipsilateral periacetabular opacities.

View Article and Find Full Text PDF
Article Synopsis
  • The study aimed to evaluate the retention rates and remission outcomes of patients with axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA) who started treatment with secukinumab over 24 and 48 months.
  • Data was collected from 13 European registries, revealing that retention rates were around 51%-64%, and patients with no prior biologic treatments showed better outcomes compared to those with previous treatments.
  • The findings suggest that secukinumab remains effective over four years, with higher success rates in treatment-naïve patients compared to those who had already tried other therapies.
View Article and Find Full Text PDF
Article Synopsis
  • This study focuses on improving accuracy in MRI-guided transperineal needle placement for prostate cancer diagnosis and treatment.
  • It introduces a new method for needle steering using a data-driven, closed-loop strategy with shape sensing technology that does not depend on specific parameters.
  • In an animal model, this approach showed a notable increase in targeting precision, achieving a mean target error of only 2.2 ± 1.9 mm on the first try, marking a key advancement for future clinical applications.
View Article and Find Full Text PDF

This case series aims to characterize the development of systemic lupus erythematosus (SLE) induced by anti-tumor necrosis factor α (anti-TNFα) therapy in patients with inflammatory rheumatic diseases, namely rheumatoid arthritis (RA), spondylarthritis (SpA), and psoriatic arthritis (PsA). Patients with a diagnosis of SLE induced by anti-TNFα therapy and registered on the Rheumatic Diseases Portuguese Register (Reuma.pt) who started their first anti-TNFα between 2001 and 2020 were included.

View Article and Find Full Text PDF
Article Synopsis
  • Needle insertion using flexible bevel tip needles is a key minimally-invasive technique for prostate cancer surgery, which allows for precise navigation around sensitive anatomy.
  • The study introduces a hybrid deep learning and model-based method for predicting needle trajectory during insertion using a validated Lie-group theory approach, addressing the existing challenges in this area.
  • The proposed method shows promising results, achieving an average prediction error of 1.03 mm in needle shape across various tissue models, and demonstrates the ability to further refine the predictive model through self-supervised learning and transfer learning techniques.
View Article and Find Full Text PDF
Article Synopsis
  • - Large Granular Lymphocytic (LGL) leukemia is a rare type of cancer that often occurs alongside Rheumatoid Arthritis (RA) and is characterized primarily by low neutrophil counts.
  • - Patients may show symptoms like spleen enlargement, resembling Felty's Syndrome, and while T-LGL leukemia is usually slow-growing, improper treatment can lead to serious health issues, primarily due to frequent infections.
  • - The text discusses two cases highlighting the potential of Rituximab as an effective treatment for patients suffering from both T-LGL leukemia and RA.
View Article and Find Full Text PDF

Introduction: Biological disease-modifying antirheumatic drugs (bDMARD) have improved the clinical course and quality of life of patients with rheumatoid arthritis (RA). However, some patients failed to respond or have an insufficient response to bDMARD early in the course of the treatment.

Objectives: To determine the percentage of RA patients who need to switch due to ineffectiveness in the first year of treatment and to identify specific baseline features as possible predictors of switch due to ineffectiveness in the first year of treatment.

View Article and Find Full Text PDF

Introduction: Systemic sclerosis (SSc) is characterized by progressive fibrosis of the skin and internal organs, microvascular damage and cellular and humoral immunity abnormalities. Microvascular damage can be easily detected through nailfold videocapillaroscopy (NVC).

Materials And Methods: A retrospective study of patients with SSc and a NVC performed within the first 6 months after diagnosis was conducted.

View Article and Find Full Text PDF

The chemical composition of spilt oils from events that took place on the north-eastern coast of Brazil in 2019 and 2022 was investigated to better understand their sources, and post-spill processes. Oils from both events originated from different sources, based on their fingerprints, hydrocarbons composition and specific biomarkers, such as the C23 tricyclic terpane and oleanane. Despite the differences, the source rocks share similarities in paleoenvironments and depositional conditions and both oils suffered little weathering, mainly due to evaporation and dissolution.

View Article and Find Full Text PDF

The global market of sweet potato ( (L.) Lam.) is continuously growing and, consequently, demands greater productivity from the agricultural sector.

View Article and Find Full Text PDF

The complexity of the agroecosystem can also be assessed by the different land uses in the system and the surroundings, being a relevant way to assess the heterogeneity of the landscape and the effects on the community of interest, in this case, entomofauna. Thus, the objective of this work is to verify how the use of soil in the surroundings of Chilean lettuce horticultural systems, in the Coquimbo Region, alters the entomological community of the crop. Insect sampling was conducted (February 2021 to March 2022) using yellow pan traps.

View Article and Find Full Text PDF

Aims: to test the measurement properties of the Portuguese version of the Commissioning for Quality in Rheumatoid Arthritis Patient-Reported Experience Measure (CQRA-PREM) for patients with rheumatoid arthritis (RA).

Methods: This cross-sectional clinical field study recruited adult patients with RA during rheumatology appointments of a Portuguese rheumatology center. Patients completed the Portuguese version of CQRA-PREM, composed of 7 domains and 24 questions.

View Article and Find Full Text PDF
Article Synopsis
  • The study aimed to determine whether the modified 28-joint disease activity index (DAPSA28) or the 28-joint disease activity score with C-reactive protein (DAS28-CRP) is better for monitoring disease activity in psoriatic arthritis (PsA) when the full joint count is unavailable.
  • Analysis of real-world data from over 3,000 European patients revealed that at the 6-month mark, DAPSA28 provided similar remission rates to DAPSA, but DAS28-CRP showed significantly higher rates of both remission and response.
  • The results suggest that DAPSA28 is preferable to DAS28-CRP when conducting assessments without a full joint count due to the
View Article and Find Full Text PDF

Purpose: This research aims to investigate the role of transformational leadership and organizational culture - encompassing Clan, Adhocracy, Hierarchical and Market Cultures - in the context of work-life balance for healthcare workers. It aims to present a comparison of observations made pre and mid-pandemic.

Design/methodology/approach: A structured questionnaire was utilized to collect data from a varied sample of 355 employees (258 before and 97 during the pandemic) representing multiple sectors and positions within a hospital.

View Article and Find Full Text PDF
Article Synopsis
  • * Researchers measured whole blood mRNA and plasma proteins in a group of 35 biologic-naïve axSpA patients before and after 14 weeks of TNFi treatment, finding significant changes in inflammatory markers and immune cell compositions between responders and non-responders.
  • * A predictive model was created using relevant clinical and gene expression data, achieving high accuracy (AUC = 0.97) in determining who might respond positively to the treatment, suggesting that baseline immune cell
View Article and Find Full Text PDF

Objective: We aim to study association between neutrophile to lymphocyte (NLR) and platelet to lymphocyte (PLR) ratios and disease activity, and their value to predict bDMARD response. Methods: A set of spondylarthritis (SpA) patients under bDMARD registered in the Reuma.pt registry was studied.

View Article and Find Full Text PDF

A new species of the genus is described from Ngoc Linh Mountain, Kon Tum Province, in the Central Highlands of Vietnam based on integrative taxonomy, namely by combining molecular and morphological evidence. differs from all other congeners based on morphological data, allopatric distribution, and molecular divergence. In terms of genetic divergence, distinctly differs from the sister species (6.

View Article and Find Full Text PDF

Objectives: In patients with axial spondyloarthritis (axSpA) or psoriatic arthritis (PsA) initiating secukinumab, we aimed to assess and compare the proportion of patients achieving 6-, 12- and 24-month patient-reported outcomes (PRO) remission and the 24-month retention rates.

Patients And Methods: Patients with axSpA or PsA from 16 European registries, who initiated secukinumab in routine care were included. PRO remission rates were defined as pain, fatigue, Patient Global Assessment (PGA) ≤2 (Numeric Rating Scale (NRS) 0-10) and Health Assessment Questionnaire (HAQ) ≤0.

View Article and Find Full Text PDF

Introduction: Interstitial lung disease (ILD) contributes significantly to morbidity and mortality in connective tissue disease (CTD). Early detection and accurate diagnosis are essential for informing treatment decisions and prognosis in this setting. Clear guidance on CTD-ILD screening, however, is lacking.

View Article and Find Full Text PDF