NEUTRAL LIPID AND CARBOHYDRATE PRODUCTIVITIES AS A RESPONSE TO NITROGEN STATUS IN ISOCHRYSIS SP. (T-ISO; HAPTOPHYCEAE): STARVATION VERSUS LIMITATION(1).

Partitioning of the carbon (C) fixed during photosynthesis between neutral lipids (NL) and carbohydrates was investigated in Isochrysis sp. (Haptophyceae) in relation to its nitrogen (N) status. Using batch and nitrate-limited continuous cultures, we studied the response of these energy reserve pools to both conditions of N starvation and limitation.

Effect of two different long-sprint training regimens on sprint performance and associated metabolic responses.

The purpose of this study was to analyze 2 different long-sprint training programs (TPs) of equal total work load, completed either with short recovery (SR) or long recovery (LR) between sets and to compare the effects of 6 long-sprint training sessions (TSs) conducted over a 2-week period on a 300-m performance. Fourteen trained subjects performed 3 pretraining maximal sprints (50-, 100-, and 300-m), were paired according to their 300-m performance, and randomly allocated to an LR or SR group, which performed 6 TSs consisting of sets of 150, 200, or 250 m. The recovery in the LR group was double that of the SR group.

Geometric and harmonic study of the aging of the fourth rib.

One of the current reference methods, namely the Işcan method for estimating age at death, consists in the subjective observation of the sternal end of the fourth rib. In this study, we looked to identify the morphometric characteristics of the sternal end of the fourth rib that were most affected by aging by measuring them in an objective way. For this purpose, we collected measurements from the fourth rib tip of 414 French males and used mathematical algorithms derived from pattern recognition and signal processing to identify variables that reflect both geometric characteristics and serration patterns of the ribs.

Spliceosome and other novel mutations in chronic lymphocytic leukemia and myeloid malignancies.

Spliceosome mutations represent a new generation of acquired genetic alterations that affect both myeloid and lymphoid malignancies. A substantial proportion of patients with myelodysplastic syndromes (MDSs) or chronic lymphocytic leukemia (CLL) harbor such mutations, which are often missense in type. Genotype-phenotype associations have been demonstrated for one of these mutations, SF3B1, with ring sideroblasts in MDS and 11q22 deletions in CLL.

Unraveling the genetic underpinnings of myeloproliferative neoplasms and understanding their effect on disease course and response to therapy: proceedings from the 6th International Post-ASH Symposium.

Immediately after the annual scientific meeting of the American Society of Hematology (ASH), a select group of clinical and laboratory investigators in myeloproliferative neoplasms (MPN) is summoned to a post-ASH conference on chronic myeloid leukemia and the BCR-ABL1-negative MPN. The 6th such meeting occurred on December 13–14,2011, in La Jolla, California, USA, under the direction of its founder,Dr. Tariq Mughal.

The long-term outcome of hepatic artery thrombosis after liver transplantation in children: role of urgent revascularization.

Hepatic artery thrombosis (HAT), one of the most severe complications of pediatric orthotopic liver transplantation (OLT), often compromises graft and/or child survival. Of 590 OLT performed in 516 children over a 20-year period, 45 were complicated by early HAT, during the first 2 weeks after transplantation. Systematic Doppler ultrasonographic detection of HAT allowed successful surgical revascularization in 19 instances, resulting in a 20-year graft survival rate of 77% versus 24% of cases when revascularization was not attempted or failed.

Mutations affecting mRNA splicing define distinct clinical phenotypes and correlate with patient outcome in myelodysplastic syndromes.

A cohort of MDS patients was examined for mutations affecting 4 splice genes (SF3B1, SRSF2, ZRSR2, and U2AF35) and evaluated in the context of clinical and molecular markers. Splice gene mutations were detected in 95 of 221 patients. These mutations were mutually exclusive and less likely to occur in patients with complex cytogenetics or TP53 mutations.

Automated segmentation of a motion mask to preserve sliding motion in deformable registration of thoracic CT.

Purpose: Deformable registration generally relies on the assumption that the sought spatial transformation is smooth. Yet, breathing motion involves sliding of the lung with respect to the chest wall, causing a discontinuity in the motion field, and the smoothness assumption can lead to poor matching accuracy. In response, alternative registration methods have been proposed, several of which rely on prior segmentations.

TET2, a tumor suppressor in hematological disorders.

The TET family of proteins has been described a few years ago. Only recently, their roles in DNA modification, through the oxidation of methyl-cytosine, and in normal and malignant development, through the description of TET2 as a tumor suppressor have been documented. The conjunction of these findings has prompted large efforts to understand the biology of these novel entities.

Dry-land strength training vs. electrical stimulation in sprint swimming performance.

This study was undertaken to compare the effects of dry-land strength training vs. an electrical stimulation program on swimmers. Twenty-four national-level swimmers were randomly assigned to 3 groups: the dry-land strength training program (S), the electrical stimulation training program (ES), and the control (C) group.

Primitive models of ions in solution from molecular descriptions: a perturbation approach.

The development of simple, primitive model descriptions for electrolyte solutions is usually carried out by fitting the system parameters to reproduce some experimental data. We propose an alternative method, that allows one to derive implicit solvent models of electrolyte solutions from all-atom descriptions. We obtain analytic expressions for the thermodynamic and structural properties of the ions, which are in good agreement with the underlying explicit solvent representation, provided that ion association is taken into account.

B-spline explicit active surfaces: an efficient framework for real-time 3-D region-based segmentation.

A new formulation of active contours based on explicit functions has been recently suggested. This novel framework allows real-time 3-D segmentation since it reduces the dimensionality of the segmentation problem. In this paper, we propose a B-spline formulation of this approach, which further improves the computational efficiency of the algorithm.

Detection of the whole myocardium in 2D-echocardiography for multiple orientations using a geometrically constrained level-set.

The segmentation of the myocardium in echocardiographic images is an important task for the diagnosis of heart disease. This task is difficult due to the inherent problems of echographic images (i.e.

Functional analysis of the NUP98-CCDC28A fusion protein.

Background: The nucleoporin gene NUP98 is rearranged in more than 27 chromosomal abnormalities observed in childhood and adult, de novo and therapy-related acute leukemias of myeloid and T-lymphoid origins, resulting in the creation of fusion genes and the expression of chimeric proteins. We report here the functional analysis of the NUP98-coiled-coil domain-containing protein 28A (NUP98-CCDC28A) fusion protein, expressed as the consequence of a recurrent t(6;11)(q24.1;p15.

Three-reaction model for the anaerobic digestion of microalgae.

Coupling an anaerobic digester to a microalgal culture has received increasing attention as an alternative process for combined bioenergy production and depollution. In this article, a dynamic model for anaerobic digestion of microalgae is developed with the aim of improving the management of such a coupled system. This model describes the dynamics of inorganic nitrogen and volatile fatty acids since both can lead to inhibition and therefore process instability.

Widening spectrum of liver angiosarcoma in children.

Objectives: Liver hemangiomas are vascular tumors, which occur in the first months of life and carry risks of initial complications, but are considered to be benign histologically and to regress with time. Histologic studies suggest that a subtype, type 2 hemangioendothelioma, is akin to angiosarcoma and may have a severe long-term prognosis. We report 5 girls with type 2 hemangioendothelioma of the liver.

[Medical abortion from 12 through 14 weeks' gestation: a retrospective study with 126 patients].

Objective: To assess the efficacy of medical abortion performed according to a single protocol from 12 through 14 weeks.

Study Design: Retrospective observational study of medical abortions from 12 through 14 weeks performed from January 2007 through March 2009. The protocol combined 600 mg de mifepristone orally, followed 48 h later by 400 μg of misoprostol, administered orally, and repeated after 3h, four times a day (during two days), if patient did not begin to abort.