A method for comparing and combining cost-of-illness studies: an example from cardiovascular disease.

This paper describes a method for comparing and combining the results of various cost-of-illness (COI) studies. The method consists of seven steps: identify the study design; stratify according to the cost components; create concatenated cost components; adjust for inflation; adjust for population growth; compare cost estimates; and combine cost estimates. Based on this method, and using published data from 1986, 1993 and 1994, the cost of cardiovascular disease was estimated to be $20.