Publications by authors named "Bernard Irthum"
Article Synopsis
- Anaplastic gangliogliomas (GGGs) are rare brain tumors with unclear progression patterns; this study examined their clinical, imaging, and prognostic features in a group of 43 adult patients from a French database over a ten-year period.* -
- Patients commonly presented with neurological deficits, seizures, or increased intracranial pressure, and imaging typically showed unifocal tumors with features like enhancement and necrosis; treatment often involved surgery followed by radiotherapy.* -
- The study found that while the overall survival rates are slightly better than glioblastomas, tumor characteristics such as midline crossing and location can impact survival; however, no factors remained significant in advanced statistical analysis.*
Temozolomide is an oral cytotoxic agent that has demonstrated its interest in high grade glioma tumors. This drug can be used either concomitantly with radiotherapy or as chemotherapy. The prognosis of relapsing medulloblastoma is poor and treatment is often difficult, especially after radiotherapy.
View Article and Find Full Text PDFSupradiaphragmatic adrenocorticotropic hormone (ACTH) secreting pituitary adenomas are exceptionally encountered (14 cases previously described) and raise issues concerning their nosology and management. If surgery is the treatment of choice, the nature of surgical approach (craniotomy, transsphenoidal approach) remains controversial. To illustrate this issue, we presented two cases of supradiaphragmatic ACTH secreting pituitary adenomas successfully excised via a subfrontal approach.
View Article and Find Full Text PDFIntrathecal morphine (ITM) is commonly used for the treatment of cancer pain. There is reluctance for its use in France to treat chronic noncancer pain. In order to appreciate its popularity, efficacy, dose escalation with time, and long-term tolerance, we carried out a retrospective study in the neurosurgery departments of university teaching hospitals in France involved in intrathecal drug therapy.
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