Publications by authors named "Bernard Hedon"
Objective: To define for women at low obstetric risk methods of management that respect the rhythm and the spontaneous course of giving birth as well as each woman's preferences.
Methods: These clinical practice guidelines were developed through professional consensus based on an analysis of the literature and of the French and international guidelines available on this topic.
Results: Labor should be monitored with a partograph (professional consensus).
The French College of Obstetrics and Gynecology (CNGOF) has released its first comprehensive recommendations for clinical practices in contraception, to provide physicians with an updated synthesis of the available data as a basis for their practice. The organizing committee and the working group adopted the objective methodological principles defined by the French Authority for Health (HAS) and selected 12 themes relevant to medical professionals' clinical practices concerning contraception. The available literature was screened through December 2017 and served as the basis of 12 texts, reviewed by experts and physicians from public and private practices, with experience in this field.
View Article and Find Full Text PDFObjective: To examine if a balanced female embryo with X-autosome translocation could, during its subsequent development, express an abnormal phenotype.
Design: Preimplantation genetic diagnosis (PGD) analysis on two female carriers with maternal inherited X-autosome translocations.
Setting: Infertility center and genetic laboratory in a public hospital.
The 2012 "4 countries meeting" of the French, Dutch, British and German Societies of Gynaecology and Obstetrics (CNGOF, NVOG, RCOG, DGGG) was dedicated to the topic "Low-risk pregnancy and normal delivery". The objective was to compare how each country organises prenatal care and normal delivery. The discussion is outlined in the article and provides new opportunities to learn from each other's strengths in order to provide the highest level of care regardless of social, demographic, educational and clinical differences.
View Article and Find Full Text PDFArticle Synopsis
- This study examined the meiotic segregation of rare Robertsonian translocations (rob(13; 21) and rob(15; 22)) using fluorescence in situ hybridization (FISH) for the first time, focusing on sperm and embryos after pre-implantation genetic diagnosis (PGD).
- Results showed that a high percentage of gametes from both patients (86.3% and 87.5%) produced normal or balanced chromosomes.
- Among their embryos, only 25% and 46% were balanced, with a significant portion of unbalanced embryos being mosaic or chaotic, indicating potential risks for chromosomal abnormalities and suggesting a need for improved genetic counseling.
Objective: This study was conducted to assess the long-term efficacy and safety of a low-dose monophasic combined oral contraceptive (COC) containing 0.02 mg ethinylestradiol (EE) and 2 mg chlormadinone acetate (CMA) in a novel regimen administered daily for 24 days followed by a 4-day placebo interval.
Study Design: In this multicenter, uncontrolled, Phase III trial, 1665 subjects took the COC 0.
Article Synopsis
- This review assesses the impact of severe endometriosis on IVF outcomes and explores complications, ovarian stimulation protocols, and the progression of endometrial conditions during treatment.
- IVF is shown to be an effective infertility treatment for severe endometriosis patients, comparable in success to those without the condition, but carries risks, especially concerning ovarian function.
- Early initiation of IVF with tailored protocols and thorough patient education about retrieval risks is recommended to optimize treatment results.
Article Synopsis
- * The modified natural cycle involved centrifugation of human follicular fluid (HFF) to retrieve oocytes, resulting in the collection of two viable oocytes when initially only one was visible.
- * The technique of HFF centrifugation led to the formation of two embryos without compromising their quality, ultimately leading to a live birth in April 2008.
Article Synopsis
- Transvaginal ultrasonography is used in IVF programs to non-invasively assess uterine receptivity, aiming to improve pregnancy prediction.
- A study involving 124 patients analyzed various ultrasonographic factors, including endometrial thickness and blood flow, during key IVF stages.
- The best predictors of pregnancy involved a combination of end-diastolic blood flow, endometrial pattern, and thickness, achieving around 81% sensitivity and specificity, particularly effective on the day of HCG administration.
Article Synopsis
- A comparative study was conducted on protein expression in human cumulus cells from oocytes subjected to two different ovarian stimulation protocols for classical IVF, using high-resolution techniques to analyze the proteins.* -
- The findings revealed that hormonal treatment notably impacts the protein expression profile of cumulus cells, even when comparing oocytes from the same patient.* -
- Significant differences were observed in protein patterns between different patients, suggesting that cumulus protein synthesis may correlate with oocyte maturity and fertility outcomes.*
Article Synopsis
- Cardiac arrest due to postpartum hemorrhage may not respond well to traditional resuscitation techniques, prompting consideration of alternative methods like sternotomy or ECMO.
- A case study detailed a woman who experienced severe hemorrhage after a cesarean delivery, leading to cardiac arrest that did not improve for two hours before ECMO was started.
- The successful use of ECMO suggests that aggressive mechanical support may be crucial for young obstetric patients facing serious circulatory issues.
Article Synopsis
- The study aimed to evaluate how body mass index (BMI) affects the outcomes of in vitro fertilization (IVF) in infertile patients.
- A total of 573 patients were analyzed across four BMI categories during IVF cycles, revealing that obese patients required a higher dose of r-FSH for follicular development.
- Despite the increased medication dosage for obese patients, the study found that obesity did not negatively impact the overall success rates of IVF, such as implantation or pregnancy rates.
Objective: The present study aims at demonstrating the equivalence of the 28-day and 3-month formulations of triptorelin SR (sustained release) in terms of percentage of patients achieving castration levels of estradiol (<==50 pg/mL) 84 days after treatment initiation.
Design: A phase II, prospective, randomized, multicenter, open study was conducted in two parallel groups of women with endometriosis.
Setting: Academic hospitals.
Article Synopsis
- - A 28-year-old woman experienced secondary amenorrhoea due to an arteriovenous malformation (AVM), with no other symptoms besides the absence of menstrual cycles.
- - Imaging revealed the AVM, and it was successfully treated with endovascular embolization, resulting in partial thrombosis of the lesion.
- - Two months after the treatment, the woman regained her menstrual cycles, suggesting that the AVM may have been diverting blood from the endometrium, causing the amenorrhoea.
Objective: To compare the Pfannenstiel incision with transverse muscle-cutting Maylard incision in women who had cesarean delivery.
Methods: Patients were assigned randomly to a Pfannenstiel or Maylard incision. Postoperative treatment was similar for each group.
Objective: To assess the adhesive reliability of the contraceptive patch (Ortho Evra/Evra).
Design: Pooled data of 3,319 women from three contraceptive studies of up to 13 treatment cycles; a subset of 325 women of the pooled data from warm and humid climates; and 30 women from a three-period, crossover exercise study.
Setting: 184 centers.