Alzheimer's disease disrupts domain-specific and domain-general processes in numerosity estimation.

Introduction: This study investigated how Alzheimer's Disease (AD) affects numerosity estimation abilities (e.g., finding the approximate number of items in a collection).

Cingulate cortex in pre-MCI cognition.

Studies of Alzheimer's disease over the years have focused on the prodromal stage, or mild cognitive impairment (MCI), in order to understand its evolution and to diagnose this pathology early. More recently, research has focused on an even earlier stage (pre-MCI) characterized in particular by a cognitive complaint. The purpose of this chapter is, first, to describe the different concepts defining pre-MCI, which refers to cognitive or memory complaint, and to define this concept based on biologic markers (abnormal proteins and neuroimaging).

Impact of mild traumatic brain injury on cingulate functions.

Mild traumatic brain injury (mTBI) is a condition of normal neuroimaging, because conventional MRI is not sensitive to brain lesions. Neurocognitive deficits persist for years after injury in 15% of patients. Persistent TAI can continue after the trauma and contribute to progressive disability.

Ageing stereotypes and prodromal Alzheimer's disease (AGING): study protocol for an ongoing randomised clinical study.

Introduction: The number of older people diagnosed with amnestic mild cognitive impairment (aMCI), the prodromal state of Alzheimer's disease (AD), is increasing worldwide. However, some patients with aMCI never convert to the AD type of dementia, with some remaining stable and others reverting to normal. This overdiagnosis bias has been largely overlooked and gone unexplained.

[Subjective cognitive impairment and Alzheimer's disease: a two year follow up of 51 subjects during two years].

Subjective cognitive impairment (SCI) is defined by a state of subjective complaint, without objective cognitive deterioration. Amnestic mild cognitive impairment (A-MCI), which characterizes a syndrome between normal cognitive aging and early Alzheimer's disease (E-AD), is preceded by A-MCI from many years. SCI expresses a metacognitive impairment.

APOE ε4 Genotype and the Risk for Subjective Cognitive Impairment in Elderly Persons.

The authors compared the risk for subjective cognitive impairment (SCI) between carriers of the apolipoprotein E ε4 (APOE ε4) allele (cases) and APOE ε4 noncarriers (controls). SCI was assessed by a validated self-reported questionnaire. The authors used multivariable logistic regression analyses to compute odds ratios and 95% confidence intervals adjusted for age, sex, education, and marital status.

Approximate quantification in young, healthy older adults', and Alzheimer patients.

Forty young adults, 40 healthy older adults, and 39 probable AD patients were asked to estimate small (e.g., 25) and large (e.

Strategic aspects of young, healthy older adults', and Alzheimer patients' arithmetic performance.

Forty young adults, 40 healthy older adults, and 23 probable AD patients were asked to solve simple subtraction problems (e.g., 9-3; 14-9) in a choice condition and in a no-choice condition.

Pharmacology of Alzheimer's disease: appraisal and prospects.

Ten years after the introduction of the first drug, tacrine, in the treatment of Alzheimer's disease, it seems appropriate to re-appraise the pharmacological processes of innovation in the research field of dementia. The aim of this review is to pinpoint concrete improvements achieved in this field, regarding experimental methods and clinical evaluation of the compounds, as well as the neurochemistry of the disease and cellular targets to consider in priority. This review deals with this objective in three parts: (1) assessment of current therapeutics, (2) discussion of the experimental models and clinical practices and (3) prospective drugs of the future.

Oxidative stress level in circulating neutrophils is linked to neurodegenerative diseases.

Alzheimer's and Parkinson's diseases are the most common neurodegenerative conditions. Oxidative lesions are a hallmark of both diseases, but the respective roles of systemic and cerebral dysfunction are not elucidated. As circulating neutrophils are the most powerful sources of reactive oxygen species, we measured oxidative stress levels in resting neutrophils from 44 Alzheimer's and Parkinson's disease patients and compared them to 40 healthy counterparts.

Alzheimer's disease disrupts arithmetic fact retrieval processes but not arithmetic strategy selection.

Three groups of healthy younger adults, healthy older adults, and probable AD patients, performed an addition/number comparison task. They compared 128 couples of additions and numbers (e.g.

Value of (99m)Tc-ECD SPET for the diagnosis of dementia with Lewy bodies.

Despite improved diagnostic accuracy, differentiation of dementia with Lewy bodies (DLB) and Alzheimer's disease (AD) on the basis of clinical findings remains problematic. The purpose of this retrospective study was to evaluate the utility of technetium-99m ethyl cysteinate dimer (ECD) single-photon emission tomography (SPET) as a potential tool for the diagnosis of DLB and discrimination from AD. Cerebral perfusion patterns detected by (99m)Tc-ECD SPET were compared in patients presenting with a probable diagnosis of DLB ( n=34) or AD ( n=28).