Publications by authors named "Bernard E Cabana"
Background: Hypericin is a potent inhibitor of glioma growth in vitro. To examine whether synthetic oral hypericin can be tolerated by patients with recurrent malignant gliomas (anaplastic astrocytoma and glioblastoma) and to investigate its efficacy against these tumors, the authors undertook an open-label, sequential dose escalation/de-escalation tolerance study.
Methods: Patients with documented recurrent or progressive malignant gliomas who had received standard radiation therapy with or without chemotherapy were included.