A pilot study of estrogen receptor (ER) expression in pancreatic ductal adenocarcinoma (PDAC).

Background: Pancreatic ductal adenocarcinoma (PDAC) is the most common pancreatic neoplasm with 5-year survival as low as 6%. It is therefore imperative to explore potential treatment avenues to improve survival in these groups of patients. Anti-estrogenic hormone therapy (AEHT) is well-tolerated and has been used in estrogen receptor (ER) subgroups of breast cancer.

Majority of flat epithelial atypia diagnosed on biopsy do not require surgical excision.

Background: Borderline risk lesions such as flat epithelial atypia (FEA) are increasingly being diagnosed on biopsy. The need for surgery is being debated. In this study, we determined the frequency of histological upgrade following a diagnosis of FEA on biopsy and evaluated potential predictive factors.

Histopathologically proven siderotic cataract with disintegrated intralenticular foreign body.

Cataract formation may be an indicator of early siderosis and has been associated with intralenticular foreign bodies. We report a unique case of histopathologically proven lens siderosis in a young man with a preceding history of trauma but no signs of retained intraocular foreign body. He presented with a total white cataract with brownish deposits on anterior capsule and underwent cataract surgery for same followed by histopathological staining of anterior capsule for iron deposits.

Clinics in diagnostic imaging (143). Perianal mucinous adenocarcinoma arising from chronic fistula-in-ano.

We report a case of mucinous adenocarcinoma arising in the perianal soft tissue in association with chronic fistula-in-ano in a 43-year-old man who had a relapse of perianal pain and bloody discharge after six years of defaulted follow-up. He underwent magnetic resonance (MR) and computed tomography imaging with correct identification of the disease entity on imaging. Mesh-like septations and an enhancing solid component with high diffusion-weighted imaging (DWI) and intermediate apparent diffusion coefficient signals were observed.

Leiomyomatosis peritonealis disseminata presenting as omental torsion.

Leiomyomatosis peritonealis disseminata is usually asymptomatic or mimics widespread malignancy; acute presentation is rare. We describe a patient with right iliac fossa and lower abdominal pain. Two masses were detected via computed tomography, but at surgery, one of these implanted leiomyomas had undergone acute omental torsion.

Lobular neoplasia of the breast: 68 years on.

Lobular neoplasia, which encompasses both atypical lobular hyperplasia and lobular carcinoma in situ, is traditionally considered a risk lesion that indicates an increased relative risk of the affected woman for subsequent breast cancer development. Recent molecular genetic information on this entity, however, has provided additional insights into the biology of this incompletely understood disease. Recognition of variants of lobular carcinoma in situ has also led to dilemmas in optimal management, and the advent of pre-operative core biopsies for radiologically detected lesions has created uncertainties regarding how best to handle incidentally discovered lobular neoplasia on these biopsy cores.

Flat epithelial atypia: concepts and controversies of an intraductal lesion of the breast.

Image-guided biopsies of the breast play an integral role in the diagnostic evaluation of mammographically detected calcifications. Apart from cancer, on these biopsies we are increasingly recognising a hitherto poorly categorised group of benign to atypical entities collectively known as columnar cell lesions. A variant of this theme is flat epithelial atypia, a columnar lesion characterised by mildly atypical epithelial cells.