Contribution of cardiac surgeons in transcatheter aortic valve replacement activity in France.

Objectives: This study provides a thorough analysis of cardiac surgeons' involvement in transcatheter aortic valve replacement (TAVR) activities in France, covering decision-making, procedural roles, training, and outcome analysis.

Methods: A nationwide survey was sent to all cardiac surgeons and all cardiac surgery trainees in France. Subgroup analysis was performed for age, status (established versus in-training), and type of practice facility.

Mechanistic insights into the interaction between epilepsy and sleep.

Epidemiological evidence has demonstrated associations between sleep and epilepsy, but we lack a mechanistic understanding of these associations. If sleep affects the pathophysiology of epilepsy and the risk of seizures, as suggested by correlative evidence, then understanding these effects could provide crucial insight into the basic mechanisms that underlie the development of epilepsy and the generation of seizures. In this Review, we provide in-depth discussion of the associations between epilepsy and sleep at the cellular, network and system levels and consider the mechanistic underpinnings of these associations.

Miniaturized Iontronic Micropipettes for Precise and Dynamic Ionic Modulation of Neuronal and Astrocytic Activity.

The composition of the extracellular milieu can vary significantly under physiological and pathological conditions, thereby altering the functional set point of brain cells. While global changes in the extracellular milieu are known to affect network activity, a detailed understanding of how specific changes in ion species impact individual cells remains elusive. Current modulation methods involve the use of diluted salts, such as KCl, where lack of precise control complicates data interpretation.

Dynamic regulation of cortical interneuron wiring.

Inhibitory interneurons play crucial roles in modulating the circuits and activity patterns of the cerebral cortex. In particular, interneurons must adapt to changes in cortical activity and environmental information to drive appropriate responses. In this review, we focus on the latest progress in our understanding of the processes that regulate interneuron wiring adaptability.

Learning by Concordance as a Tool for Paediatric Dental Traumatology Education.

Introduction: A learning by concordance (LbC) tool including 33 vignettes was developed jointly by teachers from the Y and the University of X to train undergraduate dental students in paediatric dental traumatology. The aim of this work was to present a learning tool not yet described in the community of dental educators. The method was presented on two different electronic platforms to two groups of students.

A summer in the greater Paris: trophic status of peri-urban lakes shapes prokaryotic community structure and functional potential.

With more than 12 million inhabitants, the Greater Paris offers a "natural laboratory" to explore the effects of eutrophication on freshwater lake's microbiomes within a relative restricted area (~ 70 km radius). Here, a 4-months survey was carried out during summertime to monitor planktonic microbial communities of nine lakes located around Paris (Île-de-France, France) of comparable morphologies, yet distinct trophic statuses from mesotrophic to hypereutrophic. By thus minimizing the confounding factors, we investigated how trophic status could influence prokaryotic community structures (16S rRNA gene sequencing) and functions (shotgun metagenomics).

Molecular basis for azetidine-2-carboxylic acid biosynthesis.

Azetidine-2-carboxylic acid (AZE) is a long-known plant metabolite. Recently, AZE synthases have been identified in bacterial natural product pathways involving non-ribosomal peptide synthetases. AZE synthases catalyse the intramolecular 4-exo-tet cyclisation of S-adenosylmethionine (SAM), yielding a highly strained heterocycle.

The association of social deprivation index and contraception care in a statewide contraceptive access initiative.

Objectives: To examine the association of social deprivation index (SDI) and contraception care in a statewide contraceptive access initiative (PATH4YOU) in Indiana.

Study Design: A cross-sectional analysis was performed to examine associations of participant's chosen appointment type and contraceptive method with age and SDI.

Results: Of the 1201 participants, 45.

Diurnal dynamics of the Zbtb14 protein in the ventral hippocampus are disrupted in epileptic mice.

Our previous in silico data indicated an overrepresentation of the ZF5 motif in the promoters of genes in which circadian oscillations are altered in the ventral hippocampus in the pilocarpine model of temporal lobe epilepsy in mice. In this study, we test the hypothesis that the Zbtb14 protein oscillates in the hippocampus in a diurnal manner and that this oscillation is disrupted by epilepsy. We found that Zbtb14 immunostaining is present in the cytoplasm and cell nuclei.

Has AlphaFold3 achieved success for RNA?

Predicting the 3D structure of RNA is a significant challenge despite ongoing advancements in the field. Although AlphaFold has successfully addressed this problem for proteins, RNA structure prediction raises difficulties due to the fundamental differences between proteins and RNA, which hinder its direct adaptation. The latest release of AlphaFold, AlphaFold3, has broadened its scope to include multiple different molecules such as DNA, ligands and RNA.

Costs analysis of integrating group interpersonal therapy into HIV care services in Senegal.

Introduction: Group Interpersonal Therapy (IPT), an evidence-based treatment of depression recommended by the WHO mhGAP Intervention Guide, was implemented through a task-shifting approach in Senegal, as a treatment for depressed people living with HIV (PLWH). Since a description of the resources used and the implementation costs incurred is necessary to inform policymakers better, this study aimed to estimate the costs associated with its implementation.

Methods: Intervention costs were analyzed using an "ingredients-based costing approach" from the provider's perspective.

Technical Validation of a Spatial Tracking Configuration for Augmented and Co-Localized Medical Assistance Under Gravity Variations in Parabolic Flights.

Introduction: Augmented reality is a promising technology for enhancing remote medical assistance. It assists users by directly projecting the relevant virtual assistance in the real world at the right moment and at the right location. This modality is called colocalization but has not been validated in parabolic flights.

Stakeholder Perspectives on the Role of Peer Mentors in the Implementation of Long-Acting Antiretroviral Therapy for Use by Adolescents and Young People in Western Kenya: Findings from a Formative Study, KuwaFree! LiveFree!

Long-acting antiretroviral treatment (LA ART) is a forthcoming option for adolescents and young people living with HIV (AYPLHIV), but perspectives on using peer mentors to implement LA ART for AYPLHIV are unknown. We conducted seven focus group discussions ( = 58 participants) from November 2021 to April 2022 in Kenya with four stakeholder groups, including AYPLHIV, healthcare providers, advocates, and policymakers. We used inductive coding and thematic analysis.

Safety and efficacy of the automated suture system in valvular heart surgery: a multicenter, prospective registry.

Background: In the last years, the Cor-Knot device has been increasingly used in heart valve surgery. Our aim was to investigate the incidence of valvular complications in patients who underwent valvular surgery using the Cor-Knot device in multicentric cohorts at one-year follow-up.

Methods: Three hundred and sixty-eight patient underwent heart valve repair or replacement surgery using automated titanium suture fasteners in four cardiothoracic surgery departments between September 2018 and January 2020.

RNA-TorsionBERT: leveraging language models for RNA 3D torsion angles prediction.

Motivation: Predicting the 3D structure of RNA is an ongoing challenge that has yet to be completely addressed despite continuous advancements. RNA 3D structures rely on distances between residues and base interactions but also backbone torsional angles. Knowing the torsional angles for each residue could help reconstruct its global folding, which is what we tackle in this work.

(Cyanobacteria) chemical fingerprint reveals local molecular adaptation.

Unlabelled: can colonize a wide variety of environments (e.g., freshwater, brackish, alkaline, or alkaline-saline water) and develop dominant and even permanent blooms that overshadow and limit the diversity of adjacent phototrophs, especially in alkaline and saline environments.

Case Series of Infection-Related Glomerulonephritis in Quebec Indigenous Peoples.

Rationale: Infection-related glomerulonephritis (IRGN) is an immune-mediated glomerulonephritis caused by extra-renal infectious diseases. There has been an important shift in epidemiology in recent years, with a significant proportion of adults affected. The incidence of IRGN is higher amongst Indigenous populations and especially in those with multiple comorbidities.

Muscle composition is not a prognostic factor for muscle strength recovery after anterior cruciate ligament surgery by hamstring tendon autograft.

Purpose: For the athlete, anterior Cruciate Ligament (ACL) rupture and its surgical management are often a turning point in their career. Success and time to return to sport are essential parameters for athletes and their support staff, so it is critical to understand the prognostic factors influencing return to sport after anterior cruciate ligament reconstruction (ACLR). The aim of this study was to determine the influence of hamstring muscle composition on muscle power following ACLR with autogenous hamstring grafts.

Exploratory study of erosion in cultivated organic soils using cesium-137 measurements.

Concerns about the sustainability of cultivated organic soils in Montérégie (Quebec, Canada), which can also be identified as histosols, led to this exploratory study aimed at quantifying erosion in these soils by using cesium-137 (Cs) measurements. Soil samples were taken from organic soils in twenty-two fields, and their Cs contents were measured by gamma spectrometry. The estimated mean annual erosion rates (±SD), adjusted with cropping history, ranged from 0.

Assessment of a next generation sequencing gene panel strategy in 133 patients with negative thrombophilia screening.

Background: Although heritability of venous thromboembolism (VTE) is high, the thrombophilia screening appears to be positive only in a minority of VTE patients. Adding rare variants screening to identify VTE missing heritability still requires further assessment.

Objectives: We report the results of a panel strategy after 3 years of application.