Synopsis of recent research by authors named "Bernard Brugg"
- Bernard Brugg's research emphasizes the intersection of neurobiology and cardiology, particularly how neuronal activity influences cardiac function and structure through studies such as the neuro-cardiac junction (NCJ) and its effects on patient-derived cardiomyocytes using innovative organ-on-chip technologies.
- His investigations delve into therapeutic strategies targeting caspase-2 for diseases like Alzheimer's and nonalcoholic steatohepatitis, proposing new small peptidomimetics that demonstrate selective inhibition, representing a significant advancement in drug development for these conditions.
- Brugg's work also highlights the implications of neurotransmission dysregulation in neurodegenerative diseases, investigating how neuronal network disruptions can lead to trans-synaptic degeneration, emphasizing the need for synapto-protective strategies in the treatment of chronic and acute neurological disorders.
