Determinants of high cost in multiple sclerosis patients: a claims and chart review study.

Objective: To identify factors associated with high cost multiple sclerosis (MS) patients using integrated administrative claims and medical charts data.

Methods: This study identified newly diagnosed MS patients (≥18 years) in a large United States managed care claims database between 1 January 2007 and 30 April 2011 using the ICD-9-CM code (340.xx).

Cost and consequences of noncompliance to oral bisphosphonate treatment.

Background: Despite the favorable efficacy, safety, and cost-effectiveness profile of bisphosphonate (BIS) treatment for osteoporosis (OP), patient compliance remains suboptimal. A longer follow-up period could help to better characterize patient behavior as well as the predictors of noncompliance because of the extended durations of osteoporosis and time to a fracture.

Objective: To determine health care outcomes associated with compliance and noncompliance to BIS therapy in women diagnosed with OP.