Cloning of rabbit Kir6.1, SUR2A, and SUR2B: possible candidates for a renal K(ATP) channel.

In rabbit proximal tubules, a basolateral ATP- and taurine-sensitive K(+) channel (K(ATP)) was shown to be involved in the regulation of the basolateral K(+) conductance as a function of the rate of apical Na(+) entry. To establish the molecular identity of this channel, we used degenerated primers to look for cDNA transcripts for an inwardly rectifying K(+) channel (Kir6.1 and Kir6.