Publications by authors named "Bernadette Vaz"
A Multimodal Cardioprotection Strategy During Cardiac Surgery: The ProCCard Study.
J Cardiothorac Vasc Anesth
August 2023
Objective: The ProCCard study tested whether combining several cardioprotective interventions would reduce the myocardial and other biological and clinical damage in patients undergoing cardiac surgery.
Design: Prospective, randomized, controlled trial.
Setting: Multicenter tertiary care hospitals.
Article Synopsis
- The FUTURE trial investigated whether using fractional flow reserve (FFR) to guide treatment in multivessel coronary artery disease (CAD) is more effective than traditional approaches.
- The study was a randomized trial involving 927 patients, comparing outcomes of an FFR-guided strategy with a standard strategy without FFR, focusing on major adverse cardiac events over one year.
- Results showed no significant differences in major adverse events or mortality between the two groups, indicating that FFR guidance did not provide a clear benefit in managing multivessel CAD.
Aims: Percutaneous mitral valve repair (pMVR) is a new therapeutic option for mitral valve regurgitation. Positive preliminary results in non-randomised studies have been published supporting the use of the MitraClip system in patients with secondary mitral regurgitation (MR) and poor left ventricular (LV) function contraindicated to surgery. The aim of the MITRA-FR study is to provide a higher level of evidence for the efficacy of the MitraClip device in this setting.
View Article and Find Full Text PDFObjective: Sponsors must take responsibility for the quality of trials at the best possible cost. Our objective was to describe the most frequent quality failures, how they impact trial results, and identify the most efficient monitoring strategies using published articles and reports.
Results: Errors affecting clinical trials include conception, procedures, data management, and data analysis.