Publications by authors named "Bernadach Maureen"

Background/aim: Triple-negative breast cancer (TNBC) is the most heterogeneous breast cancer subtype, posing numerous challenges in clinical decision-making. Biomarkers are essential to personalize management of TNBC patients. While tumor infiltrating lymphocytes (TILs) are validated prognostic biomarkers, the requirement for tumor biopsy limits their routine use.

View Article and Find Full Text PDF
Article Synopsis
  • - The study explored the effectiveness of combining curcumin with docetaxel for patients with advanced and metastatic breast cancer, focusing on whether this combination improved treatment response rates.
  • - Conducted across multiple centers, the research included 42 patients and aimed to compare the objective response rates and other clinical outcomes between the two treatment groups but found no significant differences.
  • - Ultimately, the study concluded that adding curcumin to docetaxel did not enhance efficacy and was deemed safe, leading to the decision to stop the trial due to lack of meaningful results, while suggesting further research with adjustments for more conclusive findings.
View Article and Find Full Text PDF

Background And Aims: The treatment of metastatic non-small-cell lung cancer (NSCLC) has been revolutionized by the arrival of immune checkpoint inhibitors (ICI). For patients without immune related adverse events (irAEs), it is recommended to continue the treatment as long as it provides clinical benefit or until unacceptable toxicity appears. The aim of our study was to evaluate survival data among patients with advanced or metastatic NSCLC following ICI discontinuation for reasons of long-term response or toxicity (irAEs).

View Article and Find Full Text PDF

Background: Presently, there are few published reports on postoperative radiation therapy for oropharyngeal and oral cavity cancers treated with IMRT/VMAT technique. This study aimed to assess the oncological outcomes of this population treated with postoperative VMAT in our institution, with a focus on loco-regional patterns of failure.

Material And Methods: Between 2011 and 2019, 167 patients were included (40% of oropharyngeal cancers, and 60% of oral cavity cancers).

View Article and Find Full Text PDF
Article Synopsis
  • The NeckTAR trial is a research study that looks at a new way to check if patients with head and neck cancer still have disease after treatment by testing for special DNA in their blood.
  • It will involve blood tests before and three months after treatment for 32 patients at four different places in France.
  • The goal is to help doctors decide whether they need to perform surgery to remove lymph nodes, which could help patients avoid unnecessary operations and improve their quality of life.
View Article and Find Full Text PDF
Article Synopsis
  • * The program combines aerobic and strengthening exercises, with a primary goal of ensuring that patients achieve at least 150 minutes of moderate-intensity physical activity per week by the end of their chemotherapy.
  • * This study is unique as most existing research focuses on physical activity after treatment, making APACAN2 the first to assess an active program during neoadjuvant chemotherapy specifically for this type of breast cancer.
View Article and Find Full Text PDF

Background: To assess the impact of nutritional status on tolerance to induction chemotherapy by docetaxel, cisplatin and 5-fluorouracil (ICT) in head and neck cancer (HNC).

Methods: Ninety-two HNC patients were included. Toxicity was assessed according to common terminology criteria for adverse events.

View Article and Find Full Text PDF
Article Synopsis
  • The study focuses on establishing patient-derived xenografts (PDX) to better understand breast cancer, particularly from patients with triple negative or luminal B types during various treatment phases.
  • It aims to enroll 85 patients over three years, collecting tumor samples and additional blood for analysis, while tracking the histomolecular characteristics of the PDX to ensure accuracy.
  • The study, titled XENOBREAST, has received ethical approval and complies with international research guidelines, with plans for data publication in medical journals and presentations at conferences.
View Article and Find Full Text PDF

Background: Triple negative breast cancer (TNBC) accounts for 10-20% of breast cancers but has no specific therapy. While TNBC may be more sensitive to chemotherapy than other types of breast cancer, it has a poor prognosis. Most TNBC relapses occur during the five years following treatment, however predictive biomarkers of metastatic relapse are still lacking.

View Article and Find Full Text PDF

Background: For patients with non-epidermal non-small-cell lung cancer (NSCLC), molecular alterations should always be investigated, especially in non-smokers, who have a very high frequency of targetable alterations (EGFR 52%; ALK 8% in particular). MET exon 14 alterations are identified in 3-4% of NSCLCs and MET gene amplification and high protein expression are associated with a poor prognosis. The French recommendations only authorize the use of capmatinib and crizotinib if the mutation concerns exon 14.

View Article and Find Full Text PDF

Umbilical skin metastases (or Sister Mary Joseph nodules) are rare. Their presence typically indicates the late manifestation of deep-seated abdominopelvic malignancy. They occur mainly in gynecological cancers, and gastrointestinal cancers in men.

View Article and Find Full Text PDF

Objectives: To determine the importance of nutritional status, social status, and inflammatory status in the prognosis of head and neck cancer.

Study Design: Single-center retrospective study of prospectively collected data.

Setting: Tertiary referral center.

View Article and Find Full Text PDF

Background: The rate of toxic deaths related to induction chemotherapy in the treatment of locally advanced head and neck cancers is unacceptable and calls into question this therapeutic strategy, which is however highly effective in terms of rate and speed of response. The purpose of the study was to investigate predictive factors of toxicity of induction chemotherapy with docetaxel, cisplatin, and 5-fluorouracil (TPF) in locally advanced head and neck cancers (LAHNC).

Methods: Between June 2009 and December 2017, 113 patients treated consecutively with TPF were included retrospectively.

View Article and Find Full Text PDF

Background: Thymic epithelial carcinomas are rare and have a poor prognosis. Treatment of thymic epithelial carcinoma is multimodal and includes surgery, post-operative radiation therapy, adjuvant and neoadjuvant chemotherapy, or exclusive chemotherapy based on disease resectability. However, there is currently no standard treatment regimen for metastatic and recurrent thymic carcinoma.

View Article and Find Full Text PDF
Article Synopsis
  • - Triple negative breast cancer (TNBC) affects 10-20% of breast cancer patients and is known for limited treatment options and high rates of metastasis within five years of treatment; however, not all patients experience metastasis.
  • - This study aims to evaluate the correlation between tumor-infiltrating lymphocytes and various blood count elements, particularly focusing on the neutrophil-to-lymphocyte ratio in patients diagnosed with TNBC.
  • - The PERCEPTION clinical trial will include patients post-treatment to identify blood count changes as potential early biomarkers for treatment response and risk of cancer relapse.
View Article and Find Full Text PDF