The intestine plays a substantial role in human vitamin B6 metabolism: a Caco-2 cell model.

Background: Vitamin B6 is present in various forms (vitamers) in the diet that need to be metabolized to pyridoxal phosphate (PLP), the active cofactor form of vitamin B6. In literature, the liver has been reported to be the major site for this conversion, whereas the exact role of the intestine remains to be elucidated.

Objective: To gain insight into the role of the intestine in human vitamin B6 metabolism.