Publications by authors named "Berna Bou Tayeh"
The crosstalk between cancer and stromal cells plays a critical role in tumor progression. Syntenin is a small scaffold protein involved in the regulation of intercellular communication that is emerging as a target for cancer therapy. Here, we show that certain aggressive forms of acute myeloid leukemia (AML) reduce the expression of syntenin in bone marrow stromal cells (BMSC).
View Article and Find Full Text PDFNatural Killer (NK) cells are potent anti-leukemic immune effectors. However, they display multiple defects in acute myeloid leukemia (AML) patients leading to reduced anti-tumor potential. Our limited understanding of the mechanisms underlying these defects hampers the development of strategies to restore NK cell potential.
View Article and Find Full Text PDFThe determinants of T cell infiltration in tumors remain largely unknown. In a recent issue of Cancer Cell, Hornburg et al. use single-cell RNA sequencing to characterize the cellular compartments of the ovarian cancer microenvironment and shed light on how tumor, immune, and stromal cells interact and shape T cell infiltration.
View Article and Find Full Text PDFArticle Synopsis
- * Vitamin D treatment decreases breast cancer growth and boosts the activity of CD8+ T cells in the tumors, suggesting a potential role in enhancing immune response against cancer.
- * However, in environments with a high-fat diet, vitamin D's positive effects on breast cancer growth and CD8+ T cell infiltration are diminished, highlighting how diet can influence cancer progression and treatment efficacy.