Publications by authors named "Berlinska E"
Article Synopsis
- RAS clustering at the cell membrane is important for how cells signal each other, but scientists aren’t sure how this happens.
- Some researchers think different parts of RAS, like the G-domain and other helpers, might play a role in this clustering.
- The authors of this text say that different factors in experiments can change results, so it’s important to control things like how much protein is used and the type of cells to get accurate conclusions about RAS interactions.
Mutations in the RAS-RAF-MEK-ERK pathway are frequent alterations in cancer and RASopathies, and while RAS oncogene activation alone affects 19% of all patients and accounts for approximately 3.4 million new cases every year, less frequent alterations in the cascade's downstream effectors are also involved in cancer etiology. RAS proteins initiate the signaling cascade by promoting the dimerization of RAF kinases, which can act as oncoproteins as well: BRAF is the most common oncogenic driver, mutated in the 8% of all malignancies.
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