[Prognostic value of a number of blood laboratory parameters in the use of erythropoiesis-stimulating agents in anemic patients with lymphoproliferative diseases].

Aim: To clarify the prognostic value of the baseline blood levels of endogenous erythropoietin (EE) and tumor necrosis factor-a (TNF-a) involved in the key components of the pathogenesis of anemia in lymphoproliferative diseases (LPD), the counts of reticulocytes and platelets (hematopoietic preservation indicators) in the use of erythropoiesis-stimulating agents (ESAs) to correct anemia syndrome (AS) in patients with LPD.

Subjects And Methods: The results of AS treatment with ESAs were analyzed in 48 patients with LPD. A study group comprised patients with chronic lymphocytic leukemia (n=1 3), indolent lymphomas (n=14), and multiple myeloma (n=21).

Side reaction caused by the perfluorocarbon emulsions in intravenous infusion to experimental animals.

The perfluorocarbon (PFC) emulsions are infusion gas-transporting media and are usually called the artificial blood. However anaphylactoid reaction were observed during intravenous infusion of PFC emulsions. The cause of side reactions is the activation of the complement system.

[Effect of emulsions of carbon perfluoride compounds on the blood plasma complement system and functional state of the rabbit brain].

Experiments were conducted in vitro on rabbits to study the effect of emulsions based on composition of carbon perfluorides (decalin perfluoride/methyl cyclohexyl piperidine perfluoride) and proxanol (P-268) on the blood complement system. It is shown that despite preservation of the composition some emulsions activate complement others fail to do this. Intravenous infusion of complement-activating emulsion in a test-dose leads to early neutropenic reaction in the peripheral blood of rabbits and intensified power of low frequency rhythms in the electrocorticogram.

[Activation of the complement system of plasma and the changes in various parameters of homeostasis in rats after intravenous administration of emulsion of organoperfluorine compounds].

Anticomplementary activity of emulsion based on the organoperfluorine compounds (PFC) perfluorodecalin and perfluorotripropylamine (7:3) has been shown in vitro. A temporary reduction of the neutrophil number up to 25% of the initial level was recorded 5 min after intravenous plethoric administration of 1.0 ml of this emulsion to rats.