Computer-generated Clinical Decision-making in the Treatment of Pulmonary Atresia with Intact Ventricular Septum.

Purpose: Pulmonary atresia with intact ventricular septum is a multifactorial disease requiring complex surgeries. The treatment route is determined based on the right ventricle (RV) size, tricuspid annulus size and coronary circulation dependency of RV. Since multiple parameters influence the post-operative success, a personalized decision-making based on computed hemodynamics is hypothesized to improve the treatment efficacy.

Microneedle arrays integrated with microfluidic systems: Emerging applications and fluid flow modeling.

Microneedle arrays are patches of needles at micro- and nano-scale, which are competent and versatile technologies that have been merged with microfluidic systems to construct more capable devices for biomedical applications, such as drug delivery, wound healing, biosensing, and sampling body fluids. In this paper, several designs and applications are reviewed. In addition, modeling approaches used in microneedle designs for fluid flow and mass transfer are discussed, and the challenges are highlighted.