Publications by authors named "Berhe G Egziabher"
Foot-and-mouth disease (FMD) is endemic to sub-Saharan Africa. To further understand its complex epidemiology, which involves multiple virus serotypes and host species, we characterized the viruses recovered from FMD outbreaks in Ethiopia during 1981-2007. We detected 5 of the 7 FMDV serotypes (O, A, C, Southern African Territories [SAT] 1, and SAT 2).
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- The phosphoprotein gene of the Peste des petits ruminants (PPR) virus vaccine strain has been cloned and its 1655-nucleotide sequence revealed two overlapping open reading frames (ORFs).
- The first ORF translates to a larger polypeptide of 509 amino acids, while the second produces a shorter protein of 177 amino acids, both of which are similar to proteins found in other morbilliviruses.
- Additionally, two types of P mRNA transcripts were identified, one of which includes an extra G residue, leading to the production of a protein similar to the V protein found in other morbilliviruses; the P protein showed the least conservation among morbillivirus proteins.
Rinderpest is an acute and highly contagious viral disease of ruminants, often resulting in greater than 90% mortality. We have constructed a recombinant vaccinia virus vaccine (v2RVFH) that expresses both the fusion (F) and hemagglutinin (H) genes of rinderpest virus (RPV) under strong synthetic vaccinia virus promoters. v2RVFH-infected cells express high levels of the F and H glycoproteins and show extensive syncytium formation.
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