[The circadian changes of plasma and blood viscosity and hematocrit in patients with ischemic stroke].

We studied the blood and plasma viscosity and hematocrit in patients with ischemic stroke and in a control group. Patients with ischemic stroke had a marked hyperviscosity and elevated hematocrit levels which were correlated with arterial hypertension, alcohol consumption and tobacco smoking. In women aged 45-55 years, viscosity and hematocrit were correlated with age that may be explained by the hormonal changes.

[The normoxic therapeutic compression effect on microcirculation in acute stroke].

The study evaluates efficacy of two hyperbaric therapeutic regimes--1,-51,1 atm and 1,2 atm in patients with an acute ischemic stroke. Acid-base equilibrium dynamics of capillary and venous blood, whole blood and plasma, platelet aggregation and lipid peroxidation were investigated. An analysis of the data revealed that, comparing to the conventional method, barotherapy in stroke is accompanied by a marked therapeutic effect.

[Eprosartan mesylate in controlling of blood pressure in patients with ischemic stroke].

In 20 patients with ischemic stroke and moderate or severe arterial hypertension the effectiveness of eprosartan mesilat (Teveten, Solway Farma, Germany) for a period of 6 months was studied. Patients received 600 mg of eprosartan mesilat daily and in 4 cases hydrochlortyaside was also added. Monotherapy with eprosartan mesilat was effective in all patients with moderate arterial hypertension and in 43.

[The comparative dynamic characteristics of the autonomic indices of the cardiovascular system in myocardial infarct patients].

A study was made of the vegetative parameters associated with the cardiac rhythm and central hemodynamics in 60 patients with myocardial infarction. In 45 patients the time course of the urinary excretion of catecholamines was examined. Regulation of cardiovascular system in patients with myocardial infarction in different time spells of the disease course was studied in relation to the particular features of the clinical picture and presence of complications.

[The development of the blood hyperviscosity syndrome in patients with a history of pulmonary artery thromboembolism].

Examination of 64 patients with prior pulmonary artery thromboembolism revealed high blood viscosity in 88% of males and 77% of females. Polycythemia and disturbed erythrocyte deformability were the causes of increased blood viscosity. The degree of disturbed blood viscosity correlated with the degree of hemodynamic disorders.

[Quantum hemotherapy in the treatment of chronic postembolic pulmonary hypertension].

Based on studying 34 patients, the authors made a conclusion that transfusion of UVI autoblood improves the pulmonary blood circulation, increases blood oxygenation and deformability of erythrocytes, decreases blood viscosity.

[Effectiveness of long-term treatment with vasodilators in patients with artificial pacemakers].

The effect of long-term use of venular and arterial vasodilators (molsidomin and nifedipin) on the clinical course and hemodynamic indices was studied in 52 patients with artificial pacemakers. The choice of vasodilator was based on an acute drug test. In the presence of hypertensive disease the calcium antagonist nifedipin was used, in cases of dilatation of the cardiac compartments molsidomin was used.

[Hemorheological aspects of the Arvin therapy of acute thromboses of the magistral veins of the lower extremities].

The rheologic blood properties were studied in patients with acute venous thrombosis during Arvin therapy. A marked correcting effect of the agent in removing the hemorheological disorders was demonstrated. It was found that the action of Arvin, linked with reduction of fibrinogen concentration, is attended by a decrease of blood viscosity, diminished aggregation of blood formed elements, and improvement of the functional condition of the microcirculatory bed during the whole course of treatment.

[Correction of blood hyperviscosity in patients with chronic post-embolic pulmonary hypertension by the method of infusion of UV-irradiated autologous blood].

Examination of 38 patients with chronic postembolic pulmonary hypertension revealed gross hemorheological disorders: increased viscosity of blood, extreme aggregation activity of blood cells, diminished property or erythrocytes to undergo deformity when circulating through the capillaries. Small amounts of UV-irradiated autologous blood were infused repeatedly for the correction of these disorders. After a course of treatment the hemorheological indices were normalized in all the patients, which was attended by improvement of the general condition and positive hemodynamic shifts.

[Hemorheology and blood thrombotic potential in pulmonary thromboembolism].

Examination of 138 patients with acute venous thrombosis of the lower limbs, which was complicated by thromboembolism of the pulmonary artery in 49 of them, showed the rheologic status to be disturbed to a greater extent in patients with pulmonary embolism than in those with acute venous thrombosis. An interrelationship between the rheologic properties and the coagulation system of the blood in various conditions of the hemostasis system was revealed. It is pointed out that pathogenetically grounded correction of the disorders of the blood coagulation and rheologic systems is necessary in choosing the method for treatment and prevention of acute venous thrombosis and pulmonary embolism.

[Changes in peripheral hemodynamics in patients with chronic circulatory insufficiency in the extremities after the treatment by reinfusion of UV-irradiated blood].

Reinfusion of the blood irradiated with the ultra-violet rays in patients with chronic insufficiency of the blood supply of the extremities leads to significant increase in the linear and volumetric blood flow rate in the damaged extremities, improvement in the microcirculation, reduction in the blood viscosity. The effect doesn't depend on the genesis of occlusion and degree of the impairement of circulation.

Effects of various nitrates on pulmonary wedge pressure in acute myocardial infarction.

122 patients with acute myocardial infarction showing a positive antianginal response to nitroglycerin were examined. With the patients under continuous haemodynamic control including pulmonary artery catheterization the circulatory response to various nitrates administered orally, sublingually or transdermally was investigated. A safe time interval was determined for each drug to ensure stability of the attained wedge pressure reduction.

[Effect of surgical trauma on the rheological properties of the blood].

The rheological properties of blood (viscosity, thrombocyte and erythrocyte aggregation activity, ability of erythrocytes for deformation) were studied in 49 patients subjected to surgical operation of different duration and volume of blood loss. It was found that a surgical trauma causes alterations in rheological properties of blood. The degree of hemorheological deviations was shown to correlate with the severity of surgery.