The study investigates the link between specific single nucleotide polymorphisms (SNPs) in immune system genes and inflammatory bowel disease (IBD) in a Mexican population, focusing on ulcerative colitis (UC) and Crohn's disease (CD).
Key findings suggest that the AG genotype of the IL-10 SNP rs1800896 increases the risk for both UC and CD, while the AA genotype is protective; the T allele of another IL-10 SNP, rs3024505, is linked to UC onset and steroid treatment.
Other SNPs (NOD2, IL23R, ATG16L1) showed no significant associations with IBD in the participants, underscoring the unique role of