Antidiabetic Potential of a Trimeric Anthranilic Acid Peptide Isolated from Malbranchea flocciformis.

Compound 3, a trimeric anthranilic acid peptide, and another three metabolites were isolated from an organic extract from the culture medium of Malbranchea flocciformis ATCC 34530. The chemical structure proposed previously for 3 was unequivocally assigned via synthesis and X-ray diffraction analysis. Tripeptide 3 showed insulinotropic properties by decreasing the postprandial peak in healthy and hyperglycemic mice.

Chemical Analysis and Antidiabetic Potential of a Decoction from Roots.

A decoction of the roots (31.6-316 mg/kg) from Cav. (Asteraceae) as well as the main component (5-150 mg/kg) showed hypoglycemic and antihyperglycemic effects in mice.

Pharmacological disadvantages in the spasmolytic effects by using the mixture known as "three toronjiles" in folk medicine.

Ethnopharmacology Relevance: In Mexico, Agastache mexicana subsp. mexicana (PT) and subsp. xolocotziana (WT), and Dracocephalum moldavica (BT), are used together as the "three toronjiles" to treat gastrointestinal spasms.

Antidiabetic Sterols from Roots.

The roots of the cactus , which grows in Northern Mexico and in the south of Arizona, are highly valued by the Pima to treat diabetes and other illnesses, such as breast pain and common cold. As part of our chemical and pharmacological investigation on medicinal plants used for treating diabetes, herein we report the hypoglycemic and antihyperglycemic action of a decoction prepared from the roots of the plant. The active compounds were a series of cholestane steroids, namely, peniocerol (), desoxyviperidone (), viperidone (), and viperidinone ().

α-Glucosidase and PTP-1B Inhibitors from .

An extract from a PDB static culture of exhibited α-glucosidase and PTP-1B inhibitory activities. Fractionation of the active extract led to the isolation of gymnoascolide A (), a γ-butenolide, and xanthones sydowinin A (), sydowinin B (), and AGI-B4 (), as well as orcinol (). Compound exhibited important inhibitory activity against yeast α-glucosidase (IC = 0.

Multi-target antidiabetic mechanisms of mexicanolides from Swietenia humilis.

Background: Swietenia humilis seeds are consumed in Mexico to treat type 2 diabetes; the antihyperglycemic effect of this species was previously demonstrated and related to the presence of tetranortriterpenoids of the mexicanolide class.

Purpose And Study Design: The present investigation was conducted to determine the mechanism of action of selected mexicanolides, including 2-hydroxy-destigloyl-6-deoxyswietenine acetate (1), methyl-2-hydroxy-3-β-tigloyloxy-1-oxomeliac-8(30)-enate (2) and humilinolide H (3), using in vivo experiments with hyperglycemic mice, and cell-based models.

Methods: Nicotinamide-streptozotocin hyperglycemic mice (50-130 mg/kg, i.

Medicinal properties of mangosteen (Garcinia mangostana L.): A comprehensive update.

Garcinia mangostana L. (Clusiaceae) is a tropical tree native to Southeast Asia known as mangosteen which fruits possess a distinctive and pleasant taste that has granted them the epithet of "queen of the fruits". The seeds and pericarps of the fruit have a long history of use in the traditional medicinal practices of the region, and beverages containing mangosteen pulp and pericarps are sold worldwide as nutritional supplements.

Antihyperalgesic activity of a mexicanolide isolated from Swietenia humilis extract in nicotinamide-streptozotocin hyperglycemic mice.

Swietenia humilis Zucc. (Meliaceae) seeds are used in Mexico for the treatment of type 2 diabetes mellitus. Mexicanolides are the main hypoglycemic and antihyperglycemic compounds of the species.

Antinociceptive and hypoglycaemic evaluation of Conyza filaginoides (D.C.) Hieron Asteraceae.

Objectives: This work was undertaken to assess the antinociceptive and hypoglycaemic properties of a quantified extract of Conyza filaginoides (CFOE), as well as the antinociceptive potential of rutin, the main active compound of the plant, in normoglycaemic and/or hyperglycaemic mice (nicotinamide-streptozotocin, NA-STZ).

Methods: The antinociceptive effect of CFOE was evaluated using the writhing, hotplate and formalin tests in mice. Rutin was also examined with the formalin test.

Hypoglycemic and antihyperglycemic effects of phytopreparations and limonoids from Swietenia humilis.

An aqueous extract from the seeds of Swietenia humilis (31.6-100mg/kg bw) lowered (p<0.05) blood glucose levels in normal and nicotinamide-streptozotocin (NA-STZ)-induced hyperglycemic mice.

Quality control tests for the crude drug of Conyza filaginoides.

Context: Conyza filaginoides (D.C.) Hieron (Asteraceae) is a medicinal Mexican plant highly prized in contemporary Mexico for the treatment of upset stomach and diabetes.