Versatile Dimerisation Process of Translocator Protein (TSPO) Revealed by an Extensive Sampling Based on a Coarse-Grained Dynamics Study.

Translocator protein (TSPO), a mitochondrial membrane protein, has been extensively studied, and its role is still debated and continues to be enigmatic. From a structural perspective, despite availability of atomic structures from different species, the possible oligomeric state and its 3D structure remains elusive. In the present study, we attempted to study dynamics of TSPO from the perspective of oligomerization.