How Nanoparticle Physicochemical Parameters Affect Drug Delivery to Cells in the Retina via Systemic Interactions.

Minor changes in the composition of poloxamer 188-modified, DEAE-dextran-stabilized (PDD) polybutylcyanoacrylate (PBCA) nanoparticles (NPs), by altering the physicochemical parameters (such as size or surface charge), can substantially influence their delivery kinetics across the blood-retina barrier (BRB) in vivo. We now investigated the physicochemical mechanisms underlying these different behaviors of NP variations at biological barriers and their influence on the cellular and body distribution. Retinal whole mounts from rats injected in vivo with fluorescent PBCA NPs were processed for retina imaging ex vivo to obtain a detailed distribution of NPs with cellular resolution in retinal tissue.

Self-similarity of solitary waves on inertia-dominated falling liquid films.

We propose consistent scaling of solitary waves on inertia-dominated falling liquid films, which accurately accounts for the driving physical mechanisms and leads to a self-similar characterization of solitary waves. Direct numerical simulations of the entire two-phase system are conducted using a state-of-the-art finite volume framework for interfacial flows in an open domain that was previously validated against experimental film-flow data with excellent agreement. We present a detailed analysis of the wave shape and the dispersion of solitary waves on 34 different water films with Reynolds numbers Re=20-120 and surface tension coefficients σ=0.

Thermographic laser Doppler velocimetry.

We propose a point measurement technique for simultaneous gas temperature and velocity measurement based on thermographic phosphor particles dispersed in the fluid. The flow velocity is determined from the frequency of light scattered by BaMgAl10O17:Eu2+ phosphor particles traversing the fringes like in conventional laser Doppler velocimetry. Flow temperatures are derived using a two-color ratio method applied to the phosphorescence from the same particles.