STUDY OF THE BIOACTIVE COMPOUNDS CONTENT IN THE FLOWERS OF POLIANTHES TUBEROSA L. INTRODUCED BY GREEN TECHNOLOGIES.

The content of bioactive compounds of perennial, fragrant species of tuberose or Polianthes tuberosa L. representing the genus Polianthes L., asparagus (Asparagaceae Juss) family, highly decorative and widely accepted in the perfumery industry and extremely sensitive to environmental conditions, native to Mexico, was studied based on of raw materials of the flowers of the said plant introduced to five different locations of the BBG with various exposition and soil content by green technologies.

FORMULATION THERMORESPONSIVE NANOCOMPOSITE HYDROGELWITH EMBEDDED PLGA NANOPARTICLES CONTAINING CYTOTOXIC AGENT.

The aim of the study was to develop and characterize the nanocomposite in-situ hydrogel as local drug delivery system of cytotoxic agent. In-situ hydrogel consisting of 15% thermosensitive (Poloxamer 407) and 1% mucoadhesive (sodium alginate) polymers was selected as the optimal formulation by the conducted studies. The influence of nanoparticle concentration on gelation time and temperature has been experimentally established.

BIOPHARMACEUTICAL UNDERSTANDING OF FORMULATION PREPARATION VARIABILITY OF PLGA NANOPARTICLES LOADED WITH ERYSIMUM EXTRACT.

The purpose of this study was to evaluate effect of process and formulation variables on the preparation of Erysimum extract loaded PLGA nanoparticles. The influence of the various biopharmaceutical factors such as type of organic solvent, type and concentration of surfactant, polymer concentration in the organic phase, ratio of organic phase and water phase were studied. Modified emulsification solvent evaporation method was used for preparation of nanoparticles.

; INTRODUCTION OF AROMATIC PLANTS IN THE BATUMI BOTANICAL GARDEN AND THEIR RESEARCH FOR THE CONTENT OF BIOLOGICALLY ACTIVE COMPOUNDS.

The research objectives were to study the introduction process of different aromatic and spice plants in the Batumi Botanical Garden and the content of bioactive compounds in aromatic plants introduced and grown in the soil and climatic conditions of the garden.; Among the aromatic plants introduced to the BBG by the authors, the following species are having full vegetative and generative development in the open ground:Cuminum cyminum L.; Polianthes tuberosa L.

FORMULATION OF BIODEGRADABLE POLYMERIC NANOPARTICLES CONTAINING CYTOTOXIC SUBSTANCE OF PLANT ORIGIN.

Formulation of novel drug delivery system is one of the approaches for improvement of pharmacological activity of drugs. This implies encapsulation of the API into the biocompatible polymeric material. Objective of the research was formulation of biodegradable amino acid based polyesteramide nanoparticles composing cytotoxic substance of plant origin.

EXTRACTION AND CHARACTERIZATION OF HUMIC SUBSTANCES FROM SPHAGNUM PEAT PELOIDS.

The objective of the research was development extraction process of humic substances from sphagnum peat peloids, selection of extragent and characterization of humic substances. The objects of the research: Kolkheti peat peloids (Ispani, Anaklia, Churia, Chirukhi, Peranga) of different formation phases. Research was held using modern instrumental methods of analysis: UV spectrophotometer, Scanning Electron Microscopy, Centrifuge, Dry oven, Ultraturax.

STUDY OF PHYSICAL AND TECHNOLOGICAL FEATURES AND CHEMICAL COMPOSITION OF CLAYS PREVALENT IN ADJARA REGION.

The Region of Adjara is one of the most interesting region by existence of mineral resources, which is not only untapped also not studied. At this stage of study, our purpose was: to research physical features and a chemical composition of biologically active substances in the clays spread in Adjara. In particular, we determined the fractional content and particle size of samples, density, humidity, fluidity, Petrographic studies and X-ray diffraction, also existence of amino and fatty acids.

[STUDY OF CYTOTOXIC ACTIVITY OF METHANOL EXTRACTS OF THE ENDEMIC PLANT OF THE GENUS ERYSIMUM OF THE ADJARIAN FLORISTIC DISTRICT OF GEORGIA].

According to the results, investigated methanolic extracts of endemic plant from Adjarian floristic region of Georgia do not have specific cytotoxicity against the cell lines of breast adenocarcinoma MCF-7 human, which is typical, e.g., for plant pigment curcumin.

[COMPARATIVE ANALYSIS OF ANTIBACTERIAL EFFECT OF PHYTOANTIBIOTICS AND ANTIBIOTICS].

The objective of this study was to determine the antibacterial activity of individual medicines and containing sum of the phyto-extracts against the bacteria causing nosocomial infections in compare to antibiotics. In the investigation were involved four strains of gram-negative bacteria Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus and Acinetobacter spp. Each object was investigated on antibiotic resistance using Kirby-Bauer diffusion method on 22 types of antibiotics.

[Analysis of some species of magnolia introduced to west georgia, on content of aporphine alkaloids and their biological activity].

The goal of research was study of vegetative organs of Magnolia species introduced to west Georgia on qualitative and quantitative content of aporphine alkaloids and evaluate cytotoxic activity of total alkaloids from M. officinalis and M. glauca against A-549, DLD-1 and WS-1.

Analysis of Perilla nankinensis decne essential oil using gas chromatography coupled with time-of-flight mass spectrometry.

Perilla is the genus of herbaceous plants of Lamiaceae family. The essential oil of Perilla is believed to be essential part of the herb. It was claimed to have anti-inflammatory, anti-hyperlipidemia, antioxidative and antimicrobial activities.

[Perilla nankinensis Decne by using melt granulation method].

The aim of the research was to work out the technology and tablet composition from the overground parts of the Perilla nankinensis Decne on the base of complex research. The dry extract was prepared from dried overground parts of perilla introduced in Georgia. The structural-mechanical and technological character of tablets and their masses were identified by the known methodic.

[Study on the separation process of pharmacological active total alkaloids from Chelidonium majus L. growing in Georgia].

In present article was studied the separation process of pharmacological active total alkaloids from Chelidonium majus L. growing in Georgia. Alkaloids were extracted from medicinal herbal material and separated by liquid extraction, diluents gas and a microfiltration through membrane equipment.

[The study of mineral composition of peloids spread in Kobuleti region].

Unlabelled: Therapeutic muds or so called peloids belong to useful minerals. They contain therapeutic active substances (micro and macro elements, vitamins, bio stimulators etc.), animated bodies and they show expressed therapeutic effectiveness.

Development of solid, dosage forms of medicinal drugs from indoline group alkaloids.

According to biopharmaceutical investigations, the regimen of the tablets of alkaloid containing new galenic preparation of indoline and indole group - Vinkabral, Vingerbin has been developed. Also, the preparation technology was worked out and it has been defined that optimal method of tabletting new galenic formulations, such as Vincabral and Vingerbin is direct pressing by using polifunctional additional formulations - Proslov SMCC (siliced methylceluslose) and Glikonat Sodium of Starch. Their influence on the technological characteristics are studied, so as the proportion of additional compounds are defined.

[Extraction of pharmacologically active alkaloids from Vinca species].

From the Genius Vinca the drugs have been received, arbitrally named: Vingerbin- with anthyarithmic activity, Vincabral-for improvement of brain blood circulation and leicobetin-as stimulator of leicopoesis. The investigations has been performed for creation of rational, resource saving, rentable phyto technologies. As a result, the liquid extraction general schema is provided for receipt of indolic alkaloids from plants V.

[Technology of production and biological activity of toothpaste from Rubus idaeus].

Composition and the technology of manufacturing of toothpaste from extract of blackberry with anti-inflammatory activity have been developed. Toothpaste contains the following ingredients (g): Blackberry extract - 3.0 5.

[Radio protective drug production from fresh leaves of Aloe arborescens Mill].

Nowadays, phytogenous drugs are wildly used as radio protective substances. The aim of the research was to study radio protective characteristics of aloe juice fraction and to develop new technology for radio protective drug production. Technological scheme for getting the drug in two stages.

[Creation of phytovaleologic drugs].

This is a new field of knowledge in medical sciences that means "Healthy Way of Life". Based on the data of medical plants and on the results of Phytochemical and Pharmacological studies, carried out in preliminary experiments, there are cultivated compositions of Valeological substances, potentially having radio protective activity. As the basis for the selection of raw materials and their correlation in mixture, there were taken the data of spontaneous analysis of chemical composition having pharmacological (radio protective) activity of various compositions.

[Development of inhalation powder formulation of gentamicin sulphate].

Aminoglycosides, including gentamicin, are considered among the most useful classes of antibiotics for treating Pseudomonas aeruginosa infections. The major drawback of aminoglycosides is the need for their relatively high-dose intravenous administration, which carries the potential for systemic toxicity. Granulometry analysis of gentamicin sulfate powder (substance) has shown, that generally it consists of large particles, and thus is not suitable for inhalation.

[Technology of vitamins containing double layer suppositories].

At present ascorbic acid and cyanocobalamin are widely used in medical practice. Often they are administered simultaneously; chemically they are incompatible, as ascorbic acid (redox compound) inactivates cyanocobalamin. The combination of ascorbic acid and cyanocobalamin is the problem of pharmacy.

Antiradical and antioxidant activity of total anthocyanins from Perilla pankinensis decne.

The purpose of this work comprise the assessment of the antioxidant activity of total anthocyanins from Perilla pankinensis samples (TAPP) by different analytical methods: 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging, total antioxidant activity, total reducing activity, superoxide anion radical scavenging, hydrogen peroxide scavenging and metal chelating activities. Total antioxidant activity was measured according to ferric thiocyanate method. alpha-Tocopherol and trolox, which water-soluble analogue of tocopherol were used as references antioxidant compounds.