The implementation of a value-based learning health system for preventative care in Ontario, Canada.

Objective: While value-based learning health systems may address challenges associated with the integrative delivery of therapeutic lifestyle management in usual care, the extent to which they have been evaluated in real-world settings have remained limited.

Methods: To explore the feasibility and user-experiences, associated with the first-year implementation of a preventative Learning Health System (LHS), consecutive patients were evaluated following referral from primary and/or specialty care providers from the Halton and Greater Toronto Area in Ontario, Canada, between December 2020 and December 2021. The integration of a LHS into medical care was facilitated using a digital e-learning platform, and consisted of exercise, lifestyle, and disease-management counselling.

Tecovirimat Treatment of People With HIV During the 2022 Mpox Outbreak : A Retrospective Cohort Study.

Background: The recent mpox outbreak has disproportionately affected people with HIV (PWH) and resulted in the first widespread use of the novel antiviral tecovirimat. Whether treatment outcomes differ between PWH and those without HIV is unknown.

Objective: To compare the clinical presentation and treatment outcomes of PWH and HIV-negative persons with mpox virus (MPXV) infection treated with tecovirimat.

Evaluation of a web-based weight loss intervention in overweight cancer survivors aged 50 years and younger.

Purpose: Half of adult cancer survivors under age 50 years are obese. Excess body weight is associated with cancer recurrence, and effective weight loss interventions for younger cancer survivors are needed. Commercially available, online weight loss programmes are readily accessible, but few have been studied in this population.

A personalized, multi-platform nutrition, exercise, and lifestyle coaching program: A pilot in women.

The aim of this pilot study was to examine if a personalized web-based multi-platform nutrition, exercise, and lifestyle coaching program, supported weight loss and the reduction of chronic disease risk factors in overweight or obese women. Twenty-eight women completed the program, which represented 50% of those who provided baseline data. The program consisted of a one-year curriculum with daily exercise, nutritional habits, and health behaviour lessons along with access to a one-on-one coach.

International Society of Sports Nutrition position stand: meal frequency.

Position Statement: Admittedly, research to date examining the physiological effects of meal frequency in humans is somewhat limited. More specifically, data that has specifically examined the impact of meal frequency on body composition, training adaptations, and performance in physically active individuals and athletes is scant. Until more research is available in the physically active and athletic populations, definitive conclusions cannot be made.

A randomized, double-blind, placebo-controlled pilot study of a probiotic in emotional symptoms of chronic fatigue syndrome.

Chronic fatigue syndrome (CFS) is complex illness of unknown etiology. Among the broad range of symptoms, many patients report disturbances in the emotional realm, the most frequent of which is anxiety. Research shows that patients with CFS and other so-called functional somatic disorders have alterations in the intestinal microbial flora.

Recovery from a cycling time trial is enhanced with carbohydrate-protein supplementation vs. isoenergetic carbohydrate supplementation.

Background: In this study we assessed whether a liquid carbohydrate-protein (C+P) supplement (0.8 g/kg C; 0.4 g/kg P) ingested early during recovery from a cycling time trial could enhance a subsequent 60 min effort on the same day vs.

Plant based dietary supplement increases urinary pH.

Background: Research has demonstrated that the net acid load of the typical Western diet has the potential to influence many aspects of human health, including osteoporosis risk/progression; obesity; cardiovascular disease risk/progression; and overall well-being. As urinary pH provides a reliable surrogate measure for dietary acid load, this study examined whether a plant-based dietary supplement, one marketed to increase alkalinity, impacts urinary pH as advertised.

Methods: Using pH test strips, the urinary pH of 34 healthy men and women (33.

Postexercise muscle glycogen recovery enhanced with a carbohydrate-protein supplement.

Purpose: This study assessed whether liquid carbohydrate-protein (C+P) supplements, ingested early during recovery, enhance muscle glycogen resynthesis versus isoenergetic liquid carbohydrate (CHO) supplements, given early or an isoenergetic solid meal given later during recovery (PLB).

Methods: Two hours after breakfast (7.0 kcal.

The role of protein and amino acid supplements in the athlete's diet: does type or timing of ingestion matter?

Rather than the age-old debate regarding overall protein and amino acid needs of athletes, this paper focuses on the importance of timing and type of protein and amino acid ingestion relative to both muscle growth and exercise performance. Evidence discussed comes from definitive measurement techniques including net protein balance determinations (for acute studies) or quantification of muscle size or strength (for chronic studies) First, recent data indicate that consuming a small meal of mixed macronutrient composition (or perhaps even a very small quantity of a few indispensable amino acids) immediately before or following strength exercise bouts can alter significantly net protein balance, resulting in greater gains in both muscle mass and strength than observed with training alone. With aerobic exercise, some evidence suggests immediate postexercise (but perhaps not pre-exercise) supplementation is also beneficial.

Effects of ribose supplementation on repeated sprint performance in men.

This study used a randomized, placebo-controlled, crossover design to evaluate the effects of oral ribose supplementation on short-term anaerobic performance. After familiarization, subjects performed 2 bouts of repeated cycle sprint exercise (six 10-second sprints with 60-second rest periods between sprints) in a single day. After the second exercise, bout subjects ingested 32 g of ribose or cellulose (4 x 8-g doses) during the next 36 hours.

Effects of prohormone supplementation in humans: a review.

Despite a relative dearth of information on their effects, supplementation with prohormones has become a popular practice. Unlike synthetic anabolic-androgenic steroids, many of these over-the-counter androgens are produced endogenously by adrenal, gonadal and peripheral steroidogenic pathways as part of the normal sexual and reproductive hormonal milieu. It has been contended that peripheral enzymatic conversion of these prohormones to testosterone or nortestosterone (via ingestion of androstenedione/androstenediol or 19-nor-androstenedione/androstenediol, respectively) might lead to anabolic and/or ergogenic effects.

[Oxytocic use and duration of labor under peridural ambulatory analgesia].

Objective: Extradural analgesia is associated with an increase duration of labor and oxytocin use.

Material And Methods: We conducted a study of walking during active labor under extradural analgesia among 41 women. This group, with uncomplicated pregnancies, was similar to associate with a usual-care group according to the following criteria: maternal age, parity, gestational age, Bishop's score at the admission, and labor entrance mode.

[3-dimensional (3D) echography in obstetrics. Advantages and limits].

Three-dimensional ultrasound (3D) offers new options in imaging modes: such as simultaneous rotation and translation of the three perpendicular planes displayed, surface rendering, or transparent mode providing an imaging of structures with high echogenicity (bones, skull). This new imaging mode is extending the field of conventional two-dimensional ultrasound, but for now it has to be evaluated.

[Study of amniotic fluid bacterial colonization sampled by amniocentesis in cases with premature rupture of membranes. Prospective multicenter study].

Objective: To determine the relationship between bacterial colonization of the amniotic fluid sampled by amniocentesis and premature rupture of the membranes.

Methods: A prospective multicentric study conducted over a one year period in 6 maternity wards in the suburban area of Paris. Thirty-six women with premature rupture of the membranes were studied.

[Prematurity due to medical decisions. Analysis of a retrospective study of 18 maternity hospitals in the periphery of Paris].

We have analysed induced prematurity in a retrospective study of 18 maternity hospitals located in the area of Paris: the Ile-de-France. The rate of induced prematurity was 1.4%, whereas the total rate of prematurity in our study was of 4.

[Computer-assisted model of weight gain during pregnancy].

The goal of this study was to modelize the evolution of "ideal" weight gain during pregnancy and to generate automatically the appropriate diet. This computerized model has been developed on a microcomputer and has two units: the first unit calculates the "ideal" weight gain during pregnancy, based on the curves of Rosso which show that weight gain is not linear with term and depends of the prepregnancy weight. The second unit calculates the appropriate diet which is depending for the first visit on height, prepregnancy weight and weight gain and for the followed visits on weight gain and the diet situation of the previous visit.

[The value of C-reactive protein in the detection of chorioamnionitis in cases of premature rupture of membranes].

In a context of premature rupture of the membranes, the authors compare the sensitivity and ability to predict the onset of chorio-amnionitis of the conventional clinical signs (hyperthermia, fetal tachycardia, discolored amniotic fluid) and paraclinical signs (hyperleukocytosis and bacteriology of the amniotic fluid) with those of the assay of C reacting protein in the maternal plasma. The latter test is apparently more sensitive and of greater positive predictive value in this disorder.

[System of decision support in obstetrics. The computerization of prenatal consultations].

The aim of this study was to realize a prototype of a computer-aided decision support for prenatal visits. He has been developped on a microcomputer. We used procedural programming to represent the medical knowledge.

Evaluation of the benefit of setting up a decentralised obstetric-surgical structure in order to reduce maternal mortality and transfers in the Ivory Coast.

Our purpose is to study the way to reduce maternal mortality when introducing a structured obstetric and surgical center to a community previously without such a center. The study was done in Ivory Coast, where such a structure was set up in 1982 in a rural hospital at Divo. It has been observed that with such a structure there are no more transfers of women from Divo to the teaching hospital at Cocody, and a reduction in maternal mortality at Divo.

Decentralization of maternity care.

One of the main reasons for the high maternal mortality rates in developing countries is the need to transfer patients long distances to city hospitals when they develop complications. Local obstetric facilities would relieve this situation.

Neonatal meningitis due to Gardnerella vaginalis.

A case of meningitis due to Gardnerella vaginalis occurred in a five-day-old newborn who had clinical signs of fever, polypnea and a grey complexion. After treatment with ampicillin, cefotaxime and netilmicin, the patient's condition improved, and no sequelae were observed. The bacterium isolated from a pure culture of the cerebrospinal fluid was identified by biochemical characteristics to be Gardnerella vaginalis, but it was not possible to define the source and mode of contamination.