Publications by authors named "Berangere Ricoux"
Article Synopsis
- GPR4 is a G protein-coupled receptor that responds to acidic pH and is expressed in endothelial cells, correlating with endothelial marker genes.
- GPR4-deficient mice are viable but exhibit a significantly reduced angiogenic response to VEGF without affecting their response to bFGF, indicating a specific role for GPR4 in VEGF-mediated angiogenesis.
- In tumor models, GPR4 deficiency leads to reduced tumor growth, lower VEGFR2 levels in endothelial cells, and changes in tumor cell proliferation and blood vessel characteristics.
The present study investigated the phenotype of heterozygous and homozygous neuropeptide S receptor (Npsr) deficient C57BL/6 mice in NPS- and cocaine induced hyperactivity, spontaneous and reactive locomotor activity, elevated plus maze, conditioned fear, and prepulse inhibition of the acoustic startle response. In Npsr-deficient mice, a strong reduction of spontaneous locomotor activity and of the startle magnitude was observed; heterozygous mice had an intermediate phenotype. In the other experiments, Npsr deficiency leads to no or only a very modest phenotype.
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